Evidence map›Paper›PMID 35625780›Full record

ArticleBiomedicines2022

Blood Neutrophil Counts Define Specific Clusters of Bronchiectasis Patients: A Hint to Differential Clinical Phenotypes.

Xuejie Wang, Casilda Olveira, Rosa Girón, Marta García-Clemente, Luis Máiz, Oriol Sibila, Rafael Golpe, Rosario Menéndez, Juan Rodríguez-López, Concepción Prados and 7 more

Abstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Neutrophilic inflammation in bronchiectasis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xuejie WangLung Cancer and Muscle Research Group, Pulmonology Department, Hospital del Mar-IMIM, Parc de Salut Mar, 08003 Barcelona, Spain.
Casilda OlveiraRespiratory Department, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Universidad de Málaga, 29010 Málaga, Spain.ORCID 0000-0002-6912-7400
Rosa GirónRespiratory Department, Instituto de Investigación Sanitaria, Hospital Universitario de la Princesa, 28006 Madrid, Spain.
Marta García-ClementeRespiratory Department, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.
Luis MáizRespiratory Department, Hospital Ramon y Cajal, 28034 Madrid, Spain.
Oriol SibilaRespiratory Department, Hospital Clínic, 08036 Barcelona, Spain.
Rafael GolpeRespiratory Department, Hospital Lucus Augusti, 27003 Lugo, Spain.ORCID 0000-0002-3759-5322
Rosario MenéndezRespiratory Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain.
Juan Rodríguez-LópezRespiratory Department, Hospital San Agustin, 33401 Avilés, Spain.
Concepción PradosRespiratory Department, Hospital Universitario la Paz, 28046 Madrid, Spain.
Miguel Angel Martinez-GarcíaCentro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 28220 Madrid, Spain.
Juan Luis RodriguezRespiratory Department, Hospital Clínico San Carlos, 28040 Madrid, Spain.ORCID 0000-0003-0552-2484
David de la RosaRespiratory Department, Hospital Santa Creu I Sant Pau, 08025 Barcelona, Spain.ORCID 0000-0003-0753-1771
Liyun QinLung Cancer and Muscle Research Group, Pulmonology Department, Hospital del Mar-IMIM, Parc de Salut Mar, 08003 Barcelona, Spain.
Xavier DuranScientific and Technical Department, Hospital del Mar (IMIM), 08003 Barcelona, Spain.
Jordi Garcia-OjalvoDepartment of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.ORCID 0000-0002-3716-7520
Esther BarreiroLung Cancer and Muscle Research Group, Pulmonology Department, Hospital del Mar-IMIM, Parc de Salut Mar, 08003 Barcelona, Spain.

Funding

Instituto de Salud Carlos III CIBERES 2021Instituto de Salud Carlos III FIS 18/00075Instituto de Salud Carlos III FIS 21/00215Ministerio de Ciencia y Tecnología CEX2018-000792-MMinisterio de Ciencia y Tecnología PGC 2018-101251-B-I00Sociedad Española de Neumología y Cirugía Torácica SEPAr 2020Zambon (Spain) 2020
6 · The paper itself

Abstract

We sought to investigate differential phenotypic characteristics according to neutrophil counts, using a biostatistics approach in a large-cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 1034 patients who met the inclusion criteria were clustered into two groups on the basis of their blood neutrophil levels. Using the Mann-Whitney U test to explore potential differences according to FACED and EFACED scores between the two groups, a neutrophil count of 4990 cells/µL yielded the most balanced cluster sizes: (1) above-threshold (

Indexed as

biostatistics analysesbronchiectasisbronchiectasis severity scoresclinical outcomesmultivariate analysesneutrophilic inflammationphenotypic clusters

Identifiers

PMID35625780
PMCPMC9139050

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.