Evidence map›Paper›PMID 35625772›Full record

ReviewBiomedicines2022

Colorectal Cancer Heterogeneity and the Impact on Precision Medicine and Therapy Efficacy.

Gerardo Rosati, Giuseppe Aprile, Alfredo Colombo, Stefano Cordio, Marianna Giampaglia, Alessandro Cappetta, Concetta Maria Porretto, Alfonso De Stefano, Domenico Bilancia, Antonio Avallone

Open access · goldAbstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Colon and rectal cancer: An emergent public health problem.World journal of gastroenterology · 2024
    Review
  8. Genetic alterations ofOpen life sciences · 2023
    Article
  9. Sensitivities and Dependencies ofMedicina (Kaunas, Lithuania) · 2022
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Gerardo RosatiMedical Oncology Unit, "S. Carlo" Hospital, 85100 Potenza, Italy.ORCID 0000-0001-7004-6862
Giuseppe AprileDepartment of Oncology, "San Bortolo" General Hospital, Azienda ULSS8 Berica, 36100 Vicenza, Italy.
Alfredo ColomboMedical Oncology Unit, CDC Macchiarella, 90138 Palermo, Italy.
Stefano CordioMedical Oncology Unit, "Maria Paternò Arezzo" Hospital, 97100 Ragusa, Italy.
Marianna GiampagliaMedical Oncology Unit, "S. Carlo" Hospital, 85100 Potenza, Italy.
Alessandro CappettaDepartment of Oncology, "San Bortolo" General Hospital, Azienda ULSS8 Berica, 36100 Vicenza, Italy.
Concetta Maria PorrettoMedical Oncology Unit, CDC Macchiarella, 90138 Palermo, Italy.
Alfonso De StefanoExperimental Clinical Abdominal Oncology Unit, Istituto Nazionale Tumori IRCCS-Fondazione "G. Pascale", 80121 Napoli, Italy.ORCID 0000-0003-2107-1177
Domenico BilanciaMedical Oncology Unit, "S. Carlo" Hospital, 85100 Potenza, Italy.
Antonio AvalloneExperimental Clinical Abdominal Oncology Unit, Istituto Nazionale Tumori IRCCS-Fondazione "G. Pascale", 80121 Napoli, Italy.ORCID 0000-0001-6188-5664
Ospedale San Carlo · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITOspedale San Bortolo · ITAzienda Usl 8 Arezzo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel targeted therapies for metastatic colorectal cancer are needed to personalize treatments by guiding specific biomarkers selected on the genetic profile of patients.

Indexed as

anti-HER-2immunotherapymetastatic colorectal cancerprecision medicineRAS and BRAF inhibitorsTRK inhibitors

Identifiers

PMID35625772
PMCPMC9138254
OpenAlexW4225113032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.