Evidence map›Paper›PMID 35625752›Full record

ArticleBiomedicines2022

The Impact of RIPK1 Kinase Inhibition on Atherogenesis: A Genetic and a Pharmacological Approach.

Pauline Puylaert, Isabelle Coornaert, Cédric H G Neutel, Yves Dondelinger, Tom Delanghe, Mathieu J M Bertrand, Pieter-Jan Guns, Guido R Y De Meyer, Wim Martinet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Role of necroptosis in kidney health and disease.Nature reviews. Nephrology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pauline PuylaertLaboratory of Physiopharmacology, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.
Isabelle CoornaertLaboratory of Physiopharmacology, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.
Cédric H G NeutelLaboratory of Physiopharmacology, Faculty of Medicine and Health Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.ORCID 0000-0001-7074-226X
Yves DondelingerVIB Center for Inflammation Research, 9052 Ghent, Belgium.
Tom DelangheVIB Center for Inflammation Research, 9052 Ghent, Belgium.
Mathieu J M BertrandVIB Center for Inflammation Research, 9052 Ghent, Belgium.
Pieter-Jan GunsLaboratory of Physiopharmacology, Faculty of Medicine and Health Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.ORCID 0000-0002-8640-6620
Guido R Y De MeyerLaboratory of Physiopharmacology, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.ORCID 0000-0003-3848-8702
Wim MartinetLaboratory of Physiopharmacology, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium.ORCID 0000-0003-1967-9343
University of Antwerp · BEGhent University · BE

Funding

Hercules Foundation AUHA/13/03Research Foundation - Flanders 11A2620NResearch Foundation - Flanders EOS 30826052
6 · The paper itself

Abstract

RIPK1 (receptor-interacting serine/threonine-protein kinase 1) enzymatic activity drives both apoptosis and necroptosis, a regulated form of necrosis. Because necroptosis is involved in necrotic core development in atherosclerotic plaques, we investigated the effects of a RIPK1

Indexed as

atherosclerosisnecroptosisRIPK1

Identifiers

PMID35625752
PMCPMC9138372
OpenAlexW4225132474

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.