Evidence map›Paper›PMID 35625720›Full record

ArticleBiomedicines2022

MicroRNA-26b Attenuates Platelet Adhesion and Aggregation in Mice.

Linsey J F Peters, Constance C F M J Baaten, Sanne L Maas, Chang Lu, Magdolna Nagy, Natalie J Jooss, Kiril Bidzhekov, Donato Santovito, Daniel Moreno-Andrés, Joachim Jankowski and 6 more

Open access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 5 countries.

Linsey J F PetersInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52056 Aachen, Germany.
Constance C F M J BaatenInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52056 Aachen, Germany.
Sanne L MaasInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52056 Aachen, Germany.
Chang LuDepartment of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 Maastricht, The Netherlands.
Magdolna NagyDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 Maastricht, The Netherlands.
Natalie J JoossDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 Maastricht, The Netherlands.ORCID 0000-0002-2314-4993
Kiril BidzhekovInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität München, 80337 Munich, Germany.
Donato SantovitoInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität München, 80337 Munich, Germany.ORCID 0000-0003-1811-4746
Daniel Moreno-AndrésDepartment of Biochemistry and Molecular Cell Biology, Medical School, RWTH Aachen University, 52056 Aachen, Germany.ORCID 0000-0003-2160-448X
Joachim JankowskiInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52056 Aachen, Germany.
Erik A L BiessenInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52056 Aachen, Germany.
Yvonne DöringInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität München, 80337 Munich, Germany.
Johan W M HeemskerkDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 Maastricht, The Netherlands.ORCID 0000-0002-2848-5121
Christian WeberInstitute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität München, 80337 Munich, Germany.
Marijke J E KuijpersDepartment of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6200 Maastricht, The Netherlands.ORCID 0000-0001-8987-6532
Emiel P C van der VorstInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52056 Aachen, Germany.ORCID 0000-0001-5771-6278
Maastricht University · NLRWTH Aachen University · DEInstitute of Genetic and Biomedical Research · ITLudwig-Maximilians-Universität München · DEUniversity of Bern · CH

Funding

Dutch Research Council 91619053Fritz Thyssen Foundation 10.20.2.043MNGerman Centre for Cardiovascular Research n.a.Interdisciplinary Center for Clinical Research within the faculty of Medicine at the RWTH Aachen University n.a.
6 · The paper itself

Abstract

Platelets are key regulators of haemostasis, making platelet dysfunction a major driver of thrombosis. Numerous processes that determine platelet function are influenced by microRNAs (miRs). MiR-26b is one of the highest-expressed miRs in healthy platelets, and its expression in platelets is changed in a diseased state. However, the exact effect of this miR on platelet function has not been studied yet. In this study, we made use of a whole-body knockout of

Indexed as

cardiovascular diseasesmicroRNA-26bmicroRNAsplateletsthrombosis

Identifiers

PMID35625720
PMCPMC9138361
OpenAlexW4224316216

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.