Evidence map›Paper›PMID 35625649›Full record

ArticleBiomolecules2022

Effects of Systemic or Local Administration of Mesenchymal Stem Cells from Patients with Osteoporosis or Osteoarthritis on Femoral Fracture Healing in a Mouse Model.

Esther Laguna, María Isabel Pérez-Núñez, Álvaro Del Real, Guillermo Menéndez, José A Sáinz-Aja, Laura López-Delgado, Carolina Sañudo, Alicia Martín, Remigio Mazorra, Diego Ferreño and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Esther LagunaServicio de Traumatología y Cirugía Ortopédica, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Facultad de Medicina, Universidad de Cantabria, 39008 Santander, Spain.ORCID 0000-0003-2319-9641
María Isabel Pérez-NúñezServicio de Traumatología y Cirugía Ortopédica, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Facultad de Medicina, Universidad de Cantabria, 39008 Santander, Spain.ORCID 0000-0001-6423-260X
Álvaro Del RealDepartamento de Medicina y Psiquiatría, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Facultad de Medicina, Universidad de Cantabria, 39011 Santander, Spain.ORCID 0000-0002-1057-461X
Guillermo MenéndezServicio de Traumatología y Cirugía Ortopédica, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Facultad de Medicina, Universidad de Cantabria, 39008 Santander, Spain.
José A Sáinz-AjaLaboratorio de la División de Ciencia e Ingeniería de los Materiales (LADICIM), Escuela Técnica Superior de Ingenieros de Caminos, Canales y Puertos, Universidad de Cantabria, 39005 Santander, Spain.ORCID 0000-0003-3187-4790
Laura López-DelgadoServicio de Medicina Interna, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Facultad de Medicina, Universidad de Cantabria, 39008-39011 Santander, Spain.
Carolina SañudoInstituto de Investigación Sanitaria Valdecilla (IDIVAL), Facultad de Medicina, Universidad de Cantabria, 39011 Santander, Spain.ORCID 0000-0002-4287-1336
Alicia MartínInstituto de Investigación Sanitaria Valdecilla (IDIVAL), Facultad de Medicina, Universidad de Cantabria, 39011 Santander, Spain.
Remigio MazorraServicio de Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain.
Diego FerreñoLaboratorio de la División de Ciencia e Ingeniería de los Materiales (LADICIM), Escuela Técnica Superior de Ingenieros de Caminos, Canales y Puertos, Universidad de Cantabria, 39005 Santander, Spain.ORCID 0000-0003-3533-1881
Belén García-MontesinosServicio de Cirugía Maxilofacial, Hospital Universitario Marqués de Valdecilla, 39008 Santander, Spain.
José A RianchoServicio de Medicina Interna, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Facultad de Medicina, Universidad de Cantabria, 39008-39011 Santander, Spain.ORCID 0000-0003-0691-8755
Universidad de Cantabria · ESMarqués de Valdecilla University Hospital · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to analyze the regenerative capacity of mesenchymal stem cells (MSCs) in the treatment of fractures. MSCs extracted from patients with osteoporotic hip fractures or hip osteoarthritis undergoing hip replacement surgeries were cultured and injected into mice with femoral fracture. Two experimental models were established, one for the systemic administration of MSCs (

Indexed as

Femoral FracturesMesenchymal Stem CellsOsteoarthritisOsteoporosisOsteoporotic FracturesAnimalsDisease Models, AnimalFracture HealingHumansMiceanimal modelbone regenerationhistological studymesenchymal stem cellsmicro-CT

Identifiers

PMID35625649
PMCPMC9138345
OpenAlexW4280580653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.