Evidence map›Paper›PMID 35625373›Full record

ArticleBiology2022

New Psychoactive Substances Consumption in Opioid-Use Disorder Patients.

Maria Alías-Ferri, Manuela Pellegrini, Emilia Marchei, Roberta Pacifici, Maria Concetta Rotolo, Simona Pichini, Clara Pérez-Mañá, Esther Papaseit, Robert Muga, Francina Fonseca and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Maria Alías-FerriAddiction Research Group, IMIM-Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain.ORCID 0000-0002-2237-8392
Manuela PellegriniNational Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-3348-5297
Emilia MarcheiNational Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-7158-6032
Roberta PacificiNational Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy.
Maria Concetta RotoloNational Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy.
Simona PichiniNational Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy.
Clara Pérez-MañáDepartment of Clinical Pharmacology, Hospital Universitari Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.ORCID 0000-0001-6343-6918
Esther PapaseitDepartment of Clinical Pharmacology, Hospital Universitari Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.
Robert MugaDepartment of Internal Medicine, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.ORCID 0000-0001-6301-431X
Francina FonsecaAddiction Research Group, IMIM-Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain.
Marta TorrensAddiction Research Group, IMIM-Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain.
Magí FarréDepartment of Clinical Pharmacology, Hospital Universitari Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain.ORCID 0000-0001-8338-7543
Universitat Autònoma de Barcelona · ESIstituto Superiore di Sanità · ITUniversitat Pompeu Fabra · ES

Funding

European Union 806996-JUSTSOGencat Suport Grups de Recerca 2017 SGR 316Gencat Suport Grups de Recerca 2017 SGR 530Instituto de Salud Carlos III FIS PI17/01962Instituto de Salud Carlos III FIS PI20/00804Instituto de Salud Carlos III RD21/0009/0001Instituto de Salud Carlos III RD21/0009/0004
6 · The paper itself

Abstract

(1) Background: Since the beginning of the 21st century, the large number and wide chemical variety of new psychoactive substances (NPS) that enter the market every year has become a public health problem. Given the rapidity with which the drug market is changing, many NPS are not clinically investigated and their effects and health risks are unknown. Drug testing is a very useful tool for this purpose, but, unfortunately, it is not very widespread in individuals with opioid-use disorder under detoxification treatment. The aim of this study is to investigate the use of illicit drugs and NPS in opioid-use disorder (OUD) patients on opioid agonist treatment. (2) Methods: A multicenter, descriptive, cross-sectional study was conducted at two addiction care services in Barcelona and Badalona, Spain. Urine samples were collected from OUD individuals attending these two centers, who anonymously donated a urine sample at the time of a periodical visit. Samples were analyzed by high-sensitivity gas chromatography-mass spectrometry (GC-MS) and ultra-high-performance liquid chromatography-high -resolution mass spectrometry (UHPLC-HRMS). (3) Results: Out of the 187 collected and analyzed urine samples, 27.3% were positive for any type of NPS and 8.6% were positive for new synthetic opioids, including fentanyl and its derivatives (NSO). Other frequently detected substances were benzodiazepines in 46.0% of samples, antipsychotics in 27.8% of samples, or cocaine and cannabis in 23.5% of samples. (4) Conclusion: A wide number of NPS, including NSO, have been detected in urine samples from an OUD population. A lack of NPS detection in standard drug screening among drug users can hide the identification of a potential public health problem.

Indexed as

new psychoactive substancesopioid-use disorderurine sample analysis

Identifiers

PMID35625373
PMCPMC9138226
OpenAlexW4224569166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.