Evidence map›Paper›PMID 35625352›Full record

ReviewBiology2022

Filamentous Thermosensitive Mutant Z: An Appealing Target for Emerging Pathogens and a Trek on Its Natural Inhibitors.

Manisha Gurnani, Abhishek Chauhan, Anuj Ranjan, Hardeep Singh Tuli, Mustfa F Alkhanani, Shafiul Haque, Kuldeep Dhama, Rup Lal, Tanu Jindal

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Manisha GurnaniAmity Institute of Environmental Science, Amity University, Noida 201301, India.
Abhishek ChauhanAmity Institute of Environmental Toxicology, Safety and Management, Amity University, Noida 201303, India.ORCID 0000-0001-6475-1266
Anuj RanjanAcademy of Biology and Biotechnology, Southern Federal University, 344006 Rostov-on-Don, Russia.ORCID 0000-0003-2592-9716
Hardeep Singh TuliDepartment of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Ambala 133207, India.ORCID 0000-0003-1155-0094
Mustfa F AlkhananiEmergency Service Department, College of Applied Sciences, AlMaarefa University, Riyadh 11597, Saudi Arabia.
Shafiul HaqueResearch and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia.ORCID 0000-0002-2989-121X
Kuldeep DhamaDivision of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly 243122, India.ORCID 0000-0001-7469-4752
Rup LalDepartment of Zoology, University of Delhi, Delhi 110021, India.
Tanu JindalAmity Institute of Environmental Toxicology, Safety and Management, Amity University, Noida 201303, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic resistance is a major emerging issue in the health care sector, as highlighted by the WHO. Filamentous Thermosensitive mutant Z (Fts-Z) is gaining significant attention in the scientific community as a potential anti-bacterial target for fighting antibiotic resistance among several pathogenic bacteria. The Fts-Z plays a key role in bacterial cell division by allowing Z ring formation. Several in vitro and in silico experiments have demonstrated that inhibition of Fts-Z can lead to filamentous growth of the cells, and finally, cell death occurs. Many natural compounds that have successfully inhibited Fts-Z are also studied. This review article intended to highlight the structural-functional aspect of Fts-Z that leads to Z-ring formation and its contribution to the biochemistry and physiology of cells. The current trend of natural inhibitors of Fts-Z protein is also covered.

Indexed as

anti-bacterial drugsantimicrobialscell divisioncytokinesisdivisomedrug discoveryFts-Z assemblymicrotubulesMRSAVRE

Identifiers

PMID35625352
PMCPMC9138142

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.