Evidence map›Paper›PMID 35625232›Full record

ArticleAntibiotics (Basel, Switzerland)2022

The Synthesis of Triazolium Salts as Antifungal Agents: A Biological and In Silico Evaluation.

Serghei Pogrebnoi, Oleg Radul, Eugenia Stingaci, Lucian Lupascu, Vladimir Valica, Livia Uncu, Anastasia Smetanscaia, Anthi Petrou, Ana Ćirić, Jasmina Glamočlija and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Serghei PogrebnoiLaboratory of Organic Synthesis, Institute of Chemistry, 3 Str. Academiei, MD-2028 Chisinau, Moldova.
Oleg RadulLaboratory of Organic Synthesis, Institute of Chemistry, 3 Str. Academiei, MD-2028 Chisinau, Moldova.
Eugenia StingaciLaboratory of Organic Synthesis, Institute of Chemistry, 3 Str. Academiei, MD-2028 Chisinau, Moldova.
Lucian LupascuLaboratory of Organic Synthesis, Institute of Chemistry, 3 Str. Academiei, MD-2028 Chisinau, Moldova.
Vladimir ValicaScientific Center for Drug Research, "Nicolae Testemitanu" State University of Medicine and Pharmacy, MD-2004 Chisinau, Moldova.
Livia UncuScientific Center for Drug Research, "Nicolae Testemitanu" State University of Medicine and Pharmacy, MD-2004 Chisinau, Moldova.ORCID 0000-0003-3453-2243
Anastasia SmetanscaiaScientific Center for Drug Research, "Nicolae Testemitanu" State University of Medicine and Pharmacy, MD-2004 Chisinau, Moldova.
Anthi PetrouDepartment of Pharmacy School of Health, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-8587-2710
Ana ĆirićMycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stanković, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia.ORCID 0000-0002-9478-5448
Jasmina GlamočlijaMycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stanković, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia.ORCID 0000-0001-6823-1137
Marina SokovićMycological Laboratory, Department of Plant Physiology, Institute for Biological Research, Siniša Stanković, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia.ORCID 0000-0002-7381-756X
Athina GeronikakiDepartment of Pharmacy School of Health, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-9894-7777
Fliur Z MacaevLaboratory of Organic Synthesis, Institute of Chemistry, 3 Str. Academiei, MD-2028 Chisinau, Moldova.ORCID 0000-0002-3094-1990

Funding

Moldovan State Program 20.80009.8007.14Moldovan State Program (2020-2023 20.80009.5007.17
6 · The paper itself

Abstract

The control of fungal pathogens is increasingly difficult due to the limited number of effective drugs available for antifungal therapy. In addition, both humans and fungi are eukaryotic organisms; antifungal drugs may have significant toxicity due to the inhibition of related human targets. Furthermore, another problem is increased incidents of fungal resistance to azoles, such as fluconazole, ketoconazole, voriconazole, etc. Thus, the interest in developing new azoles with an extended spectrum of activity still attracts the interest of the scientific community. Herein, we report the synthesis of a series of triazolium salts, an evaluation of their antifungal activity, and docking studies. Ketoconazole and bifonazole were used as reference drugs. All compounds showed good antifungal activity with MIC/MFC in the range of 0.0003 to 0.2/0.0006-0.4 mg/mL. Compound

Indexed as

antifungalCYP51dockingmicrodilution methodtriazolium salts

Identifiers

PMID35625232
PMCPMC9137982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.