ArticleAntibiotics (Basel, Switzerland)2022
Chronic Osteomyelitis of the Jaw: Pivotal Role of Microbiological Investigation and Multidisciplinary Management-A Case Report.
Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Chronic Sclerosing Osteomyelitis of Garré of the Femur in a 4-Year-Old Girl Caused by Coagulase-Negative Staphylococci: A Case Report.Children (Basel, Switzerland) · 2026Article
- Application of NGS Technology in Osteomyelitis Caused by Human Bites.Infection and drug resistance · 2026Article
- Chronic Osteomyelitis of the Jaw. Osteomyelitis.Journal of clinical and experimental dentistry · 2025Review
- Resemblances and differences between osteoradionecrosis of the jaw and medication-related osteonecrosis of the jaw.Medicine and pharmacy reports · 2024Article
- Clinical Microbial Identification of Severe Oral Infections by MALDI-TOF Mass Spectrometry in Stockholm County: an 11-Year (2010 to 2020) Epidemiological Investigation.Microbiology spectrum · 2022Article
- Histopathological Osteomyelitis Evaluation Score (HOES): Pioneering precision for diagnosing jaw osteomyelitis.Journal of oral and maxillofacial pathology : JOMFPArticle
- Article
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7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 15-year-old girl with a history of recurrent painful orofacial swelling was diagnosed on the basis of clinical findings, histopathological examination and imaging modalities as having primary chronic osteomyelitis of the jaw. Initial microbiological samples were performed but were inconclusive. She received multiple empirical antibiotic therapies and NSAIDs for 3 years without complete remission. Only MALDI-TOF (Matrix-Assisted Laser Desorption/Ionization-Time Of Flight) analysis after additional multiple microbiological bone samples with adequate techniques yielded the final diagnosis of bacterial chronic osteomyelitis of the jaw. Its management requires a multidisciplinary approach, involving oral and maxillofacial surgeons, infectiologists and microbiologists, to limit treatment failure. Antibiotic therapy without surgery for 6 months achieved the complete radiographic resolution of the CBCT (Cone Beam Computed Tomography) and the normalization of laboratory tests. After 2 years of follow-up, no relapse had been reported. Modern microbiological investigation and sampling techniques are critical for the accurate diagnosis and management of osteomyelitis of the jaw, especially in unusual and clinically misleading forms of this infection.
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