Evidence map›Paper›PMID 35625062›Full record

ArticleBrain sciences2022

Lower Prevalence of Chronic Pain in Manifest Huntington's Disease: A Pilot Observational Study.

Marianna Delussi, Vittorio Sciruicchio, Paolo Taurisano, Francesca Morgante, Elena Salvatore, Isabella Pia Ferrara, Livio Clemente, Chiara Sorbera, Marina de Tommaso

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Marianna DelussiAOU Policlinico, Applied Neurophysiology and Pain Unit, Basic Medical Sciences, Neurosciences and Sense Organs Department, Aldo Moro University, 70124 Bari, Italy.ORCID 0000-0002-5888-3024
Vittorio SciruicchioChildren Epilepsy and EEG Center, PO, San Paolo ASL (Azienda Sanitaria Locale), 70019 Bari, Italy.
Paolo TaurisanoAOU Policlinico, Applied Neurophysiology and Pain Unit, Basic Medical Sciences, Neurosciences and Sense Organs Department, Aldo Moro University, 70124 Bari, Italy.ORCID 0000-0001-6140-9326
Francesca MorganteNeurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, UK.ORCID 0000-0002-9834-3639
Elena SalvatoreAOU Federico II, Department of Advanced Biomedical Sciences, Università di Napoli, 80138 Napoli, Italy.ORCID 0000-0003-1493-5133
Isabella Pia FerraraAOU Federico II, Department of Advanced Biomedical Sciences, Università di Napoli, 80138 Napoli, Italy.
Livio ClementeAOU Policlinico, Applied Neurophysiology and Pain Unit, Basic Medical Sciences, Neurosciences and Sense Organs Department, Aldo Moro University, 70124 Bari, Italy.
Chiara SorberaIRCCS Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy.
Marina de TommasoAOU Policlinico, Applied Neurophysiology and Pain Unit, Basic Medical Sciences, Neurosciences and Sense Organs Department, Aldo Moro University, 70124 Bari, Italy.ORCID 0000-0001-6567-5373
University of Bari Aldo Moro · ITUniversity of Naples Federico II · ITASL Roma · ITCentro Neurolesi Bonino Pulejo · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pain is a minor problem compared with other Huntington Disease (HD) symptoms. Nevertheless, in HD it is poorly recognized and underestimated. So far, no study evaluated the presence of chronic pain in HD. The aim of this pilot study was to evaluate the presence and features of chronic pain in a cohort of HD gene carriers. An observational cross-sectional study was conducted in a cohort of HD gene carriers compared to not gene carriers (n.134 HD subjects, n.74 not gene mutation carriers). A specific pain interview, alongside a neurological, cognitive and behavioural examination, was performed in order to classify the type of pain, subjective intensity. A significant prevalence of "no Pain" in HD was found, which tended to increase with HD progression and a reduced frequency of pain in the last 3 months. A clear difference was found between manifest and premanifest HD in terms of intensity of pain, which did not change significantly with HD progression; however, a tendency emerges to a progressive reduction. No significant group difference was present in analgesic use, type and the site of pain. These findings could support a lower prevalence of

Indexed as

basal gangliachronic paincognitive declinefamily controlsHuntington’s diseasemanifest patientsmotor impairmentpain featurespain interviewpremanifest subjects

Identifiers

PMID35625062
PMCPMC9139182
OpenAlexW4281261749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.