Evidence map›Paper›PMID 35624962›Full record

ArticleBrain sciences2022

Analysis of a Repetitive Language Coding System: Comparisons between Fragile X Syndrome, Autism, and Down Syndrome.

Anne Hoffmann, Angela John Thurman, Audra Sterling, Sara T Kover, Lizabeth Finestack, Elizabeth Berry-Kravis, Jamie O Edgin, Andrea Drayton, Eric Fombonne, Leonard Abbeduto

Abstract read
In one paragraph

Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Consistency and reliability of automated language measures across expressive language samples in autism.Autism research : official journal of the International Society for Autism Research · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anne HoffmannDepartments of Communication Disorders and Sciences and Pediatrics, Rush University Medical Center, Chicago, IL 60612, USA.
Angela John ThurmanMIND Institute, School of Medicine, University of California Davis Health, Sacramento, CA 95817, USA.
Audra SterlingWaisman Center, Department of Communication Sciences and Disorders, University of Wisconsin-Madison, Madison, WI 53706, USA.
Sara T KoverDepartment of Speech and Hearing Sciences, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-8299-7585
Lizabeth FinestackDepartment of Speech-Language-Hearing Sciences, University of Minnesota, Minneapolis, MN 55455, USA.
Elizabeth Berry-KravisDepartments of Pediatrics, Neurological Sciences, Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL 60612, USA.
Jamie O EdginDepartment of Psychology and Sonoran UCEDD, College of Science, The University of Arizona, Tucson, AZ 85721, USA.
Andrea DraytonMIND Institute, School of Medicine, University of California Davis Health, Sacramento, CA 95817, USA.
Eric FombonneDepartments of Psychiatry and Pediatrics, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA.
Leonard AbbedutoMIND Institute, School of Medicine, University of California Davis Health, Sacramento, CA 95817, USA.ORCID 0000-0002-2311-7194

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
Research Project: Pathologic Significance of Maternal AutoantibodiesP50HD103526 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEONARD J. ABBEDUTO, Melissa Dawn Bauman · 2020 to 2026
$9.7M
Computational characterization of language use in autism spectrum disorderR01DC012033 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI FOMBONNE, ERIC · 2011 to 2021
$6.7M
Expressive Language Sampling as an Outcome MeasureR01HD074346 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ABBEDUTO, LEONARD J. · 2013 to 2017
$3.9M
NCATS NIH HHS UL1 TR001860NICHD NIH HHS P50 HD103526NICHD NIH HHS R01 HD074346NIDCD NIH HHS R01 DC012033NIH HHS NIH UL1 TR001860NIH HHS P50HD103526NIH HHS R01DC012033NIH HHS R01HD074346
6 · The paper itself

Abstract

Expressive language sampling (ELS) is a frequently used tool for language analysis, as it can be used across widely ranging cognitive and language abilities. ELS can also evaluate pragmatic language, including excessive self-repetition, which is challenging to assess with traditional standardized assessments. This study explored how a well-established ELS protocol can assess three types of linguistic self-repetition in three neurodevelopmental disabilities: fragile X syndrome (FXS), autism spectrum disorder (ASD), and Down syndrome (DS). We examined its ability to differentiate between these disorders, the relationships between repetitive language and other participant characteristics, and initial construct validity. We found that the groups with FXS and ASD differed significantly on each of the three repetitive language measure, and that the group with DS differed from either ASD or FXS on two. Cognitive ability was significantly related to phrase repetition in the group with ASD. When the groups were combined, there was evidence of convergent and divergent validity. This study extends previous research on ELS and supports its use as a means to characterize pragmatic language. It also provides information about the relationships between repetitive language and other phenotypic characteristics.

Indexed as

autismdown syndromeexpressive language samplingfragile X syndromepragmatic languagerepetitive language

Identifiers

PMID35624962
PMCPMC9139711

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.