ArticleBrain sciences2022
Modifications of Functional Human Brain Networks by Transcutaneous Auricular Vagus Nerve Stimulation: Impact of Time of Day.
Article in Brain sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Ear Thermography as a Candidate Dynamic Index of Sympathetic and Parasympathetic Activity.Sensors (Basel, Switzerland) · 2026Article
- sEEG-guided responsive neurostimulation to treat neocortical epilepsy: A multicenter retrospective study of the efficacy and safety of depth electrode-mediated neuromodulation.Epilepsia open · 2026Article
- Functional Importance Backbones of the Brain at Rest, Wakefulness, and Sleep.Brain sciences · 2025Article
- Stable Yet Destabilised: Towards Understanding Brain Network Dynamics in Psychogenic Disorders.Journal of clinical medicine · 2025Article
- Impact of Stimulation Duration in taVNS-Exploring Multiple Physiological and Cognitive Outcomes.Brain sciences · 2024Article
- Modifying functional brain networks in focal epilepsy by manual visceral-osteopathic stimulation of the vagus nerve at the abdomen.Frontiers in network physiology · 2023Article
- The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives.Frontiers in network physiology · 2023Review
- Brain Stimulation and Neuroplasticity-Series II.Brain sciences · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Transcutaneous auricular vagus nerve stimulation (taVNS) is a novel non-invasive treatment option for different diseases and symptoms, such as epilepsy or depression. Its mechanism of action, however, is still not fully understood. We investigated short-term taVNS-induced changes of local and global properties of EEG-derived, evolving functional brain networks from eighteen subjects who underwent two 1 h stimulation phases (morning and afternoon) during continuous EEG-recording. In the majority of subjects, taVNS induced measurable modifications of network properties. Network alterations induced by stimulation in the afternoon were clearly more pronounced than those induced by stimulation in the morning. Alterations mostly affected the networks' topology and stability properties. On the local network scale, no clear-cut spatial stimulation-related patterns could be discerned. Our findings indicate that the possible impact of diurnal influences on taVNS-induced network modifications would need to be considered for future research and clinical studies of this non-pharmaceutical intervention approach.
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Registered trials
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