Evidence map›Paper›PMID 35624852›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Bioactive Antioxidant Compounds from Chestnut Peels through Semi-Industrial Subcritical Water Extraction.

Christian Cravotto, Giorgio Grillo, Arianna Binello, Lorenzo Gallina, Mariló Olivares-Vicente, María Herranz-López, Vicente Micol, Enrique Barrajón-Catalán, Giancarlo Cravotto

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Molecules (Basel, Switzerland) · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Characterisation ofInsects · 2024
    Article
  8. Article
  9. Onion (Antioxidants (Basel, Switzerland) · 2024
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christian CravottoGREEN Extraction Team, INRAE, UMR 408, Avignon University, 84000 Avignon, France.ORCID 0000-0001-8382-3640
Giorgio GrilloDepartment of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Turin, Italy.ORCID 0000-0002-3538-4185
Arianna BinelloDepartment of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Turin, Italy.ORCID 0000-0002-4406-3041
Lorenzo GallinaDepartment of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Turin, Italy.ORCID 0000-0003-2033-6284
Mariló Olivares-VicenteInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernandez (UMH), 03202 Elche, Spain.
María Herranz-LópezInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernandez (UMH), 03202 Elche, Spain.ORCID 0000-0002-1819-7978
Vicente MicolInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernandez (UMH), 03202 Elche, Spain.ORCID 0000-0001-8089-0696
Enrique Barrajón-CatalánInstituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Universidad Miguel Hernandez (UMH), 03202 Elche, Spain.ORCID 0000-0001-8113-0795
Giancarlo CravottoDepartment of Drug Science and Technology, University of Turin, Via P. Giuria 9, 10125 Turin, Italy.ORCID 0000-0001-7574-7350

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chestnut peels are a poorly characterized, underexploited by-product of the agri-food industry. This raw material is rich in bioactive compounds, primarily polyphenols and tannins, that can be extracted using different green technologies. Scaling up the process for industrial production is a fundamental step for the valorization of the extract. In this study, subcritical water extraction was investigated to maximize the extraction yield and polyphenol content. Lab-scale procedures have been scaled up to the semi-industrial level as well as the downstream processes, namely, concentration and spray drying. The extract antioxidant capacity was tested using in vitro and cellular assays as well as a preliminary evaluation of its antiadipogenic activity. The temperature, extraction time, and water/solid ratio were optimized, and the extract obtained under these conditions displayed a strong antioxidant capacity both in in vitro and cellular tests. Encouraging data on the adipocyte model showed the influence of chestnut extracts on adipocyte maturation and the consequent potential antiadipogenic activity. Chestnut peel extracts characterized by strong antioxidant power and potential antiadipogenic activity were efficiently obtained by removing organic solvents. These results prompted further studies on fraction enrichment by ultra- and nanofiltration. The semi-industrial eco-friendly extraction process and downstream benefits reported here may open the door to production and commercialization.

Indexed as

adipocytesbioactivitychestnut peelspolyphenolssemi-industrial scalesubcritical water extractiontanninsultra-nano filtration

Identifiers

PMID35624852
PMCPMC9137501

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.