Evidence map›Paper›PMID 35624851›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Circulating Soluble ACE2 Plays an Independent Role to Protect against Vascular Damage in Diabetic Mice.

Chris Tikellis, Gardner N Robinson, Carlos J Rosado, Duygu Batu, Maria A Zuniga-Gutierrez, Raelene J Pickering, Merlin C Thomas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chris TikellisDepartment of Diabetes, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Gardner N RobinsonDepartment of Diabetes, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Carlos J RosadoDepartment of Diabetes, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Duygu BatuDepartment of Diabetes, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Maria A Zuniga-GutierrezDepartment of Diabetes, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Raelene J PickeringDepartment of Diabetes, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.
Merlin C ThomasDepartment of Diabetes, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia.ORCID 0000-0003-0694-8743
Monash University · AU

Funding

National Health and Medical Research Council 2016/GNT1127526
6 · The paper itself

Abstract

Circulating levels of soluble ACE2 are increased by diabetes. Although this increase is associated with the presence and severity of cardiovascular disease, the specific role of soluble ACE2 in atherogenesis is unclear. Previous studies suggested that, like circulating ACE, soluble ACE2 plays a limited role in vascular homeostasis. To challenge this hypothesis, we aimed to selectively increase circulating ACE2 and measure its effects on angiotensin II dependent atherogenesis. Firstly, in

Indexed as

Angiotensin-converting enzyme 2 (ACE2)angiotensin IIatherosclerosisdiabetesDNA minicircle

Identifiers

PMID35624851
PMCPMC9138042
OpenAlexW4280572740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.