Evidence map›Paper›PMID 35624731›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Administration of Glutaredoxin-1 Attenuates Liver Fibrosis Caused by Aging and Non-Alcoholic Steatohepatitis.

Yuko Tsukahara, Beatriz Ferran, Erika T Minetti, Brian S H Chong, Adam C Gower, Markus M Bachschmid, Reiko Matsui

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Frontiers in immunology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Chemistry and biology of enzymes in protein glutathionylation.Current opinion in chemical biology · 2023
    Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuko TsukaharaVascular Biology Section, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
Beatriz FerranVascular Biology Section, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
Erika T MinettiVascular Biology Section, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.ORCID 0000-0002-4771-791X
Brian S H ChongVascular Biology Section, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
Adam C GowerClinical and Translational Science Institute, Boston University School of Medicine, Boston, MA 02118, USA.ORCID 0000-0002-6122-7511
Markus M BachschmidVascular Biology Section, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
Reiko MatsuiVascular Biology Section, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA.
Boston University · US

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
Multidisciplinary Training in Cardiovascular ResearchT32HL007224 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAMBURG, NAOMI MIRIAM, WAINFORD, RICHARD DAVID · 1985 to 2020
$12.3M
Redox Control of Hepatic Lipid MetabolismR01DK103750 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BACHSCHMID, MARKUS MICHAEL · 2015 to 2019
$1.8M
Regulation of ischemic limb vascularization by glutaredoxin-1R01HL133013 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MATSUI, REIKO · 2016 to 2019
$1.6M
Regulation of ischemic vascularization by glutaredoxin-1 by agingR03AG051857 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MATSUI, REIKO · 2016 to 2017
$236k
NCATS NIH HHS UL1 TR001430NHLBI NIH HHS R01 HL133013NHLBI NIH HHS T32 HL007224NIA NIH HHS R03 AG051857NIDDK NIH HHS R01 DK103750NIH HHS 1UL1TR001430NIH HHS R01 HL133013NIH HHS R03 AG 051857
6 · The paper itself

Abstract

Liver fibrosis is a sign of non-alcoholic fatty liver disease progression towards steatohepatitis (NASH) and cirrhosis and is accelerated by aging. Glutaredoxin-1 (Glrx) controls redox signaling by reversing protein

Indexed as

agingglutaredoxin-1immune cellsliver fibrosisnon-alcoholic steatohepatitis

Identifiers

PMID35624731
PMCPMC9138033
OpenAlexW4282920935

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.