Evidence map›Paper›PMID 35624708›Full record

ArticleAntioxidants (Basel, Switzerland)2022

Activation of Nrf2 in Mice Causes Early Microvascular Cyclooxygenase-Dependent Oxidative Stress and Enhanced Contractility.

Dan Wang, Cheng Wang, Xueqin Hao, Gabriela Carter, Rafaela Carter, William J Welch, Christopher S Wilcox

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Dan WangDivision of Nephrology and Hypertension and Hypertension Center, Georgetown University, Washington, DC 20007, USA.ORCID 0000-0002-0302-9824
Cheng WangDivision of Nephrology, Department of Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
Xueqin HaoDepartment of Human Anatomy and Histoembryology, School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang 471023, China.
Gabriela CarterDivision of Nephrology and Hypertension and Hypertension Center, Georgetown University, Washington, DC 20007, USA.
Rafaela CarterDivision of Nephrology and Hypertension and Hypertension Center, Georgetown University, Washington, DC 20007, USA.
William J WelchDivision of Nephrology and Hypertension and Hypertension Center, Georgetown University, Washington, DC 20007, USA.
Christopher S WilcoxDivision of Nephrology and Hypertension and Hypertension Center, Georgetown University, Washington, DC 20007, USA.
Georgetown University · USHenan University of Science and Technology · CNSun Yat-sen University · CN

Funding

NIH HHS RO-1 DK109272; PO-1, HL068686; RO1-HL134511
6 · The paper itself

Abstract

Nuclear factor erythroid factor E2-related factor 2 (Nrf2) transcribes antioxidant genes that reduce the blood pressure (BP), yet its activation with tert-butylhydroquinone (tBHQ) in mice infused with angiotensin II (Ang II) increased mean arterial pressure (MAP) over the first 4 days of the infusion. Since tBHQ enhanced cyclooxygenase (COX) 2 expression in vascular smooth muscle cells (VSMCs), we tested the hypothesis that tBHQ administration during an ongoing Ang II infusion causes an early increase in microvascular COX-dependent reactive oxygen species (ROS) and contractility. Mesenteric microarteriolar contractility was assessed on a myograph, and ROS by RatioMaster™. Three days of oral tBHQ administration during the infusion of Ang II increased the mesenteric microarteriolar mRNA for p47

Indexed as

bardoxolone methylendothelinhypertensiontert-butylhydroxyquinone (tBHQ)thromboxane

Identifiers

PMID35624708
PMCPMC9137799
OpenAlexW4224986340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.