ArticleAntioxidants (Basel, Switzerland)2022
Unveiling the Antioxidant Therapeutic Functionality of Sustainable Olive Pomace Active Ingredients.
Article in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Valorization of Olive Pomace as a Source of Phenolic Compounds: Extraction Technologies, Analytical Characterization, Biological Activities, and Food Applications.Foods (Basel, Switzerland) · 2026Review
- Fortified wheat bread with dried three-phase olive pomace: effect on physicochemical, antioxidant, nutritional, and sensory characteristics.Italian journal of food safety · 2026Article
- Fig Leaf Bioactivity and Safety: Temperature Optimization and FTIR Authentication.Food science & nutrition · 2026Article
- Article
- Sustainable Valorization of Olive Oil By-Products: Green Extraction of Phytochemicals, Encapsulation Strategies, and Food Applications.Journal of food science · 2025Review
- A Comprehensive Review of the Antitumor Activity of Olive Compounds: The Case of Olive Oil, Pomace, and Leaf Extracts, Phenolic Alcohols, Secoiridoids, and Triterpenes.Antioxidants (Basel, Switzerland) · 2025Review
- The effects of experimental conditions on extraction of polyphenols from African Nutmeg peels using NADESs-UAE: a multifactorial modelling technique.Scientific reports · 2025Article
- Evaluation of the Nutritional Properties and Biodegradation of Novel Disposable Edible Tableware Made of Olive Pomace.Food science & nutrition · 2025Article
- Antitumor Effects of Chemlali and Wild Olive Tree Extracts: Role in Cell Proliferation and Apoptosis in Prostate (PC3) and Breast (MDA-MB-231) Cancer Cell Lines.BioMed research international · 2025Article
- Nutritional application of olive pomace in dairy animals: chemical composition, implications for milk quality and yield, nutrient digestibility, economics, and limitations.Archives animal breeding · 2025Review
- Synergistic benefits of olive pomace and multi-enzyme supplementation on fattening rabbit health and performance.Frontiers in veterinary science · 2025Article
- Multi-Analytical Approach for the Acid-Base, Thermal and Surface Properties Assessment of Waste Biomasses.Molecules (Basel, Switzerland) · 2024Article
- Squalene in Nanoparticles Improves Antiproliferative Effect on Human Colon Carcinoma Cells Through Apoptosis by Disturbances in Redox Balance.International journal of molecular sciences · 2024Article
- Exploring the Variability in Phenolic Compounds and Antioxidant Capacity in Olive Oil By-Products: A Path to Sustainable Valorization.Antioxidants (Basel, Switzerland) · 2024Article
- Promising Phytogenic Feed Additives Used as Anti-Mycotoxin Solutions in Animal Nutrition.Toxins · 2024Review
- Biological Properties ofAntioxidants (Basel, Switzerland) · 2024Article
- Comprehensive Review ofBiomolecules · 2024Review
- Optimization of Conditions for Microwave-Assisted Extraction of Polyphenols from Olive Pomace of Žutica Variety: Waste Valorization Approach.Antioxidants (Basel, Switzerland) · 2023Article
- Antioxidant and antiproliferative potentials of phenolic-rich extracts from biotransformed grape pomace in colorectal Cancer.BMC complementary medicine and therapies · 2023Article
- Combining Ultrafiltration and Nanofiltration to Obtain a Concentrated Extract of Purified Polyphenols from Wet Olive Pomace.Membranes · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olive pomace (OP) is the main residue that results from olive oil production. OP is rich in bioactive compounds, including polyphenols, so its use in the treatments of diseases related to oxidative stress, such as cancer, could be considered. The present work aimed to study the biological properties of different OP extracts, obtained by ohmic heating-assisted extraction and conventional heating, using water and 50% ethanol, in the treatment and prevention of colorectal cancer through Caco-2 cell models. Additionally, an in-silico analysis was performed to identify the phenolic intestinal absorption and Caco-2 permeability. The extracts were chemically characterized, and it was found that the Ohmic-hydroethanolic (OH-EtOH) extract had the highest antiproliferative effect, probably due to its higher content of phenolic compounds. The OH-EtOH induced potential modifications in the mitochondrial membrane and led to apoptosis by cell cycle arrest in the G1/S phases with activation of p53 and caspase 3 proteins. In addition, this extract protected the intestine against oxidative stress (ROS) caused by H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.