Evidence map›Paper›PMID 35624579›Full record

ArticleBiosensors2022

Signal-On Fluorescence Biosensor for Highly Sensitive Detection of miRNA-21 Based on DNAzyme Assisted Double-Hairpin Molecular Beacon.

Chenxin Fang, Yuxing Yang, Shuhao Zou, Ping Ouyang, Yang Qing, Jialun Han, Haiyu Li, Zhencui Wang, Jie Du

Abstract read
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chenxin FangCollege of Materials Science and Engineering, Hainan University, Haikou 570228, China.
Yuxing YangCollege of Materials Science and Engineering, Hainan University, Haikou 570228, China.
Shuhao ZouCollege of Materials Science and Engineering, Hainan University, Haikou 570228, China.
Ping OuyangCollege of Materials Science and Engineering, Hainan University, Haikou 570228, China.
Yang QingCollege of Materials Science and Engineering, Hainan University, Haikou 570228, China.
Jialun HanCollege of Materials Science and Engineering, Hainan University, Haikou 570228, China.
Haiyu LiCollege of Materials Science and Engineering, Hainan University, Haikou 570228, China.
Zhencui WangCollege of Materials Science and Engineering, Hainan University, Haikou 570228, China.
Jie DuCollege of Materials Science and Engineering, Hainan University, Haikou 570228, China.ORCID 0000-0002-0529-5253

Funding

National Natural Science Foundation of China 21763009Natural Science Foundation of Hainan Province 519MS020
6 · The paper itself

Abstract

Although miRNAs exist in small quantities in the human body, they are closely related to the abnormal expression of genes in diseases such as tumors. Therefore, sensitive detection of miRNAs is very important for the prevention and treatment of various tumors and major diseases. The purpose of this study is to develop a label-free sensing strategy based on the co-action of double-hairpin molecular beacons and deoxyribozymes (DNAzymes) for highly sensitive detection of miRNA-21. The target miRNA-21 promotes the assembly of DNAzyme with a complete catalytic core region. At the presence of Mg

Indexed as

Biosensing TechniquesDNA, CatalyticMicroRNAsHumansDNA, CatalyticMicroRNAsMIRN21 microRNA, humanDNAzymefluorescent biosensorhigh sensitivitymiRNA detectionsignal amplification

Identifiers

PMID35624579
PMCPMC9139022

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.