Observational studyCritical care (London, England)2022
Prone positioning improves ventilation-perfusion matching assessed by electrical impedance tomography in patients with ARDS: a prospective physiological study.
Observational study in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Determine the Effect of Prone Positioning on Lung Ventilation and Perfusion Distribution in Adults With Acute Respiratory Distress Syndrome by Electrical Impedance Tomography
Evaluate the Effect of Prone Ventilation on Ventilated-blood Flow Ratio in Patients With Acute Respiratory Distress Syndrome by Electrical Impedance Tomography
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Awake prone positioning reduces mortality, intubation, and hospital stay in acute hypoxemic respiratory failure: a systematic review and meta-analysis of 6,164 patients.BMC anesthesiology · 2026Pooled it
- Awake prone position in COVID-19-related acute respiratory failure: a meta-analysis of randomized controlled trials.BMC pulmonary medicine · 2023Pooled it
- Electrical Impedance Tomography-Guided Synergistic Intervention of Respiratory Muscle Training and Postural Adjustment for Lung Recruitment in Critically Ill Patients With Respiratory Failure.Physiological research · 2026Trial
- Electrical Impedance Tomography-Guided Airway Clearance in Elderly Patients With Severe Pneumonia: A Prospective Study.The clinical respiratory journal · 2025Trial
- Evaluation of mechanical ventilation modes in the laparoscopic perioperative period with electrical impedance tomography.PloS one · 2025Trial
- Effects of innovative modular prone positioning tools in patients with acute respiratory distress syndrome due to COVID-19 during awake prone position: a prospective randomized controlled trial.European journal of medical research · 2024Trial
- Physiologic effects of prone positioning on gas exchange and ventilation-perfusion matching in awake patients with AHRF.BMC pulmonary medicine · 2024Trial
- Lung impedance changes during awake prone positioning in COVID-19. A non-randomized cross-over study.PloS one · 2024Trial
- Prone positioning in ARDS.Intensive care medicine · 2026Review
- Clinical applications of electrical impedance tomography in pediatric subjects.Pediatric research · 2026Review
- Awake Prone Positioning in Non-Intubated Non-COVID-19 ARDS: A Comprehensive Review.Advances in respiratory medicine · 2026Review
- EIT-assessed ventilation-perfusion responses to prone positioning and inhaled nitric oxide in mechanically ventilated COVID-19-related ARDS: a prospective sequential study.Journal of intensive care · 2026Article
- Obesity: biomechanical implications for mechanical ventilation.Critical care (London, England) · 2026Review
- Evaluating lung ventilation via electrical impedance tomography during flexible bronchoscopy with supraglottic jet ventilation: a prospective pilot study.Journal of anesthesia · 2026Article
- The experiences of critical care nurses caring for patients undergoing awake prone positioning: a qualitative study.BMC nursing · 2026Article
- Ventilator-induced lung injury: from mechanisms to integrated clinical management.Frontiers in medicine · 2026Review
- Shunt: pathophysiological mechanisms and clinical implications of ineffective circulating volume.Frontiers in physiology · 2026Review
- Early prone positioning after tetralogy of fallot repair in children: a retrospective cohort study of oxygenation, safety, and short-term outcomes.Frontiers in cardiovascular medicine · 2026Article
- Prone position ventilation combined with high-flow nasal cannula oxygen therapy in patients with pulmonary infection: a retrospective study on evidence-based nursing practice.Frontiers in medicine · 2026Article
- Optimizing aerosol therapy in mechanically ventilated acute respiratory distress syndrome: a delivery-fidelity framework.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe physiological effects of prone ventilation in ARDS patients have been discussed for a long time but have not been fully elucidated. Electrical impedance tomography (EIT) has emerged as a tool for bedside monitoring of pulmonary ventilation and perfusion, allowing the opportunity to obtain data. This study aimed to investigate the effect of prone positioning (PP) on ventilation-perfusion matching by contrast-enhanced EIT in patients with ARDS.
designMonocenter prospective physiologic study.
settingUniversity medical ICU. PATIENTS: Ten mechanically ventilated ARDS patients who underwent PP.
interventionsWe performed EIT evaluation at the initiation of PP, 3 h after PP initiation and the end of PP during the first PP session. MEASUREMENTS AND MAIN
resultsThe regional distribution of ventilation and perfusion was analyzed based on EIT images and compared to the clinical variables regarding respiratory and hemodynamic status. Prolonged prone ventilation improved oxygenation in the ARDS patients. Based on EIT measurements, the distribution of ventilation was homogenized and dorsal lung ventilation was significantly improved by PP administration, while the effect of PP on lung perfusion was relatively mild, with increased dorsal lung perfusion observed. The ventilation-perfusion matched region was found to increase and correlate with the increased PaO
conclusionsProlonged prone ventilation increased dorsal ventilation and perfusion, which resulted in improved ventilation-perfusion matching and oxygenation.
trial registrationClinicalTrials.gov, NCT04725227. Registered on 25 January 2021.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.