ArticleBMC pediatrics2022
Effects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort study.
Article in BMC pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04113070 (The Effect of Childhood Overweight and Obesity and Genetic Factors on Puberty Development), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Childhood Overweight and Obesity and Genetic Factors on Puberty Development: a Prospective Cohort Study
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Paediatric penile length: a systematic review and meta-analysis.BJU international · 2026Pooled it
- Effect of dietary with Zhibai dihuang pills and gonadotropin-releasing-hormone-analogue on girls with precocious and rapidly progressive puberty.World journal of clinical cases · 2024Trial
- Association between glucolipid metabolic indicators and the risk of suspected precocious puberty in children living with obesity: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- The incidence of early and precocious puberty of children in two Chinese cities: a multi-center prospective cohort study.BMC endocrine disorders · 2025Article
- Association of obesity and menarche SNPs and interaction with environmental factors on precocious puberty.Pediatric research · 2024Article
- Association of Traditional dietary pattern with early and precocious puberty: a population-based cross-sectional study.Pediatric research · 2024Article
- Creatine Acts as a Mediator of the Causal Effect of Obesity on Puberty Onset in Girls: Evidence from Mediation Mendelian Randomization Study.Metabolites · 2024Article
- Dietary pattern and precocious puberty risk in Chinese girls: a case-control study.Nutrition journal · 2024Article
- Association of screen exposure/sedentary behavior and precocious puberty/early puberty.Frontiers in pediatrics · 2024Article
- Multi-omic analysis of precocious puberty girls: pathway changes and metabolite validation.Frontiers in endocrinology · 2024Article
- Clinical Management and Therapy of Precocious Puberty in the Sapienza University Pediatrics Hospital of Rome, Italy.Children (Basel, Switzerland) · 2023Review
- The association between sleep and early pubertal development in Chinese children: a school population-based cross-sectional study.Frontiers in endocrinology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundChildhood obesity has important effects on the onset and development of puberty. Although a number of studies have confirmed the relationship between obesity and precocious puberty, little is known about the pleiotropic genes of obesity and precocious puberty and the interaction between genes and environment. There are four objectives: (1) to analyze the incidence of precocious puberty in the general population in China; (2) to verify the direct effect of obesity on children's precocious puberty using a variety of methods; (3) to verify the effect of obesity and its risk gene polymorphism on precocious puberty in a prospective cohort study; and (4) to analyze the interaction effect of genes and environment on pubertal development.
methodsWe will conduct a multi-center prospective cohort study in three cities, which are selected in southern, central, and northern China, respectively. Primary schools in these cities will be selected by a stratified cluster random sampling method. Primary school students from grade 1 to grade 3 (6 to 10 years old) will be selected for the cohort with extensive baseline data collection, including assessment of pubertal development, family demographic information, early development, sleep pattern, dietary pattern, and physical activity. Participants will be followed up for at least three years, and long-term follow-up will depend on future funding. DISCUSSION: The findings of this multicenter prospective population-based cohort study may expand previous related puberty development research as well as provide important information on the mechanism of early puberty. Targeted interventions can also be developed to improve adolescent health problems related to puberty development based on the available evidence.
trial registrationClinicalTrials.gov Identifier: NCT04113070 , prospectively registered on October 2, 2019.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.