Evidence map›Paper›PMID 35624401›Full record

ArticleSleep & breathing = Schlaf & Atmung2023

Transoral awake state neuromuscular electrical stimulation therapy for mild obstructive sleep apnea.

Brandon Nokes, Peter M Baptista, Paula Martínez Ruiz de Apodaca, Marina Carrasco-Llatas, Secundino Fernandez, Bhik Kotecha, Phui Yee Wong, Henry Zhang, Amro Hassaan, Atul Malhotra

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03829956 (The Efficacy of Intra-oral Neuromuscular Stimulation Training on Primary Snoring), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03829956 nacompletednot on this map

The Efficacy of Intra-oral Neuromuscular Stimulation Training on Primary Snoring

TypeinterventionalSponsorSignifier Medical TechnologiesRan2019 to 2020Enrolled115ConditionsSnoring, Obstructive Sleep ApneaArmsIntraoral tongue stimulator (Snoozeal)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Benefit of adjunctive transoral neuromuscular electrical stimulation with positive airway pressure therapy: a case report.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Brandon NokesDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92121, USA. bnokes@health.ucsd.edu.ORCID 0000-0003-3515-7545
Peter M BaptistaOtorhinolaryngology Clinical Consultant, Clinica Universidad de Navarra, Pamplona, Spain.
Paula Martínez Ruiz de ApodacaMédico Especialista en Otorrinolaringología Y Cirugía de Cabeza Y Cuello, Hospital Universitario Doctor Peset, Valencia, Spain.
Marina Carrasco-LlatasMédico Especialista en Otorrinolaringología Y Cirugía de Cabeza Y Cuello, Hospital Universitario Doctor Peset, Valencia, Spain.
Secundino FernandezOtorhinolaryngology Clinical Consultant, Clinica Universidad de Navarra, Pamplona, Spain.
Bhik KotechaQueens Hospital, Barking Havering and Redbridge University Hospitals NHS Trust, Rom Valley Way, Romford, UK.
Phui Yee WongQueens Hospital, Barking Havering and Redbridge University Hospitals NHS Trust, Rom Valley Way, Romford, UK.
Henry ZhangQueens Hospital, Barking Havering and Redbridge University Hospitals NHS Trust, Rom Valley Way, Romford, UK.
Amro HassaanQueens Hospital, Barking Havering and Redbridge University Hospitals NHS Trust, Rom Valley Way, Romford, UK.
Atul MalhotraDivision of Pulmonary, Critical Care, Sleep Medicine and Physiology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92121, USA.
Barking, Havering And Redbridge University Hospitals NHS Trust · GBClinica Universidad de Navarra · ESHospital Universitario Doctor Peset · ESUC San Diego Health System · USUniversity of California San Diego · US

Funding

Is Obstructive Sleep Apnea Important in the Development of Alzheimer's DiseaseR01AG063925 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2020 to 2024
$3.7M
Single Motor Unit Genioglossus Recordings to Understand Sleep Apnea PathogenesisR01HL085188 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2008 to 2018
$3.5M
Underlying mechanisms of obesity-induced obstructive sleep apneaR01HL148436 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Atul Malhotra · 2020 to 2026
$3.4M
Sleep Apnea Endophenotypes: One Size Does Not Fit AllR01HL154926 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2021 to 2025
$3.3M
VentNet: A Real-Time Multimodal Data Integration Model for Prediction of Respiratory Failure in Patients with COVID-19R01HL157985 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, NEMATI, SHAMIM · 2022 to 2025
$2.9M
Training in the Next Generation in Respiratory ScienceT32HL134632 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL, POWELL, FRANK L. · 2017 to 2021
$2.1M
Assessment of Upper Airway Mechanics Using Newer Electromyographic TechniquesK24HL132105 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MALHOTRA, ATUL · 2016 to 2020
$611k
NHLBI NIH HHS HL134632NHLBI NIH HHS K24 HL132105NHLBI NIH HHS R01 HL085188NHLBI NIH HHS R01 HL148436NHLBI NIH HHS R01 HL154926NHLBI NIH HHS R01 HL157985NHLBI NIH HHS T32 HL134632NIA NIH HHS R01 AG063925
6 · The paper itself

Abstract

introductionObstructive sleep apnea (OSA) is a common disorder with major neurocognitive and cardiovascular sequelae. The treatment of symptomatic patients with mild OSA remains controversial given that adherence to positive airway pressure (PAP) has historically been suboptimal. With this notion in mind, we assessed a daily transoral neuromuscular electrical stimulation (NMES) device for individuals with mild OSA.

methodsThe sample represents a subset of participants with a baseline AHI 5-14.9 events/hour, drawn from a parent study which also included participants with primary snoring. Outcome measures for the current study included changes in apnea-hypopnea index (AHI), Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI) and snoring levels before and after use of the NMES. 

resultsAmong 65 participants (68% men) with median age of 49 years (range 24 to 79) and median BMI of 27.7 kg/m DISCUSSION: This NMES device has the benefit of being a treatment modality of daytime therapy which confers a high level of tolerability and patient acceptance. It alleviates the need for an in situ device during sleep and leads to improvements in OSA severity, snoring, and subjective sleep metrics, potentially crucial in mild OSA. Further studies are needed to define which individuals may benefit most from the device across the wider spectrum of OSA severity and assess long-term therapeutic outcomes.

trial registrationClinicalTrials.gov Identifier: NCT03829956.

Indexed as

Electric Stimulation TherapySleep Apnea, ObstructiveAdultAgedContinuous Positive Airway PressureFemaleHumansMaleMiddle AgedSnoringWakefulnessYoung AdultObstructive sleep apneaTransoral neuromuscular electrical stimulationUpper airway training

Identifiers

PMID35624401
PMCPMC9701243
OpenAlexW4281618045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.