Evidence map›Paper›PMID 35624391›Full record

ReviewCurrent atherosclerosis reports2022

Can We Mitigate Coronary Heart Disease Risk in Patients with Cancer?

Hasitha Manohar, Adam S Potter, Efstratios Koutroumpakis, Anita Deswal, Nicolas L Palaskas

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current atherosclerosis reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hasitha ManoharDepartment of Cardiology, Loyola University Medical Center, Maywood, IL, USA.
Adam S PotterDepartment of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Efstratios KoutroumpakisDepartment of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Anita DeswalDepartment of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Nicolas L PalaskasDepartment of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. NLPalaskas@mdanderson.org.ORCID 0000-0001-7565-1797
The University of Texas MD Anderson Cancer Center · USLoyola University Medical Center · US

Funding

Project 3: Enhanced Sensitivity of Tumors to Proton Beam Therapy: Mechanisms and Biomarkers.P01CA261669 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HONG, THEODORE S · 2021 to 2025
$14.0M
Risk prediction and longitudinal assessment of cardiotoxicity and functional capacity trajectory in NSCLC patientsR01HL157273 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LIAO, ZHONGXING · 2021 to 2025
$3.8M
NCI NIH HHS P01 CA261669NHLBI NIH HHS R01 HL157273
6 · The paper itself

Abstract

purpose of reviewThe review focuses on the shared risk factors observed between coronary heart disease and cancer, cancer therapeutics causing coronary heart disease, and potential strategies to mitigate atherosclerosis in patients with cancer. RECENT

findingsThe pathophysiology behind how traditional cardiovascular risk factors also contribute to cancer development and mortality is increasingly recognized. In addition, newer cancer therapies, such as immune checkpoint inhibitors, cause increased inflammation leading to increased cardiovascular events. Traditional coronary heart disease risk factors such as obesity, hypertension, diabetes, and hyperlipidemia also contribute to cancer development and worse cancer outcomes. Cancer therapeutics can also lead to atherosclerotic events in addition to the shared risk factors present at the time of cancer diagnosis. Understanding the pathophysiology, using multidisciplinary care teams, and developing machine learning algorithms for individualized patient care will help to mitigate the risk of coronary heart disease in patients with cancer.

Indexed as

AtherosclerosisCoronary DiseaseHyperlipidemiasNeoplasmsHumansRisk FactorsAtherosclerosisCancerMitigationRisk factors

Identifiers

PMID35624391
OpenAlexW4281679172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.