ArticleNature cancer2022
A community approach to the cancer-variant-interpretation bottleneck.
Abstract read
In one paragraph
Article in Nature cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Patritumab deruxtecan in HRNature medicine · 2025Trial
- Multiplatform curation in the development of ACMG/AMP specifications for Von Hippel-Lindau (VHL) disease.Genetics in medicine : official journal of the American College of Medical Genetics · 2026Article
- The GA4GH Categorical Variation Representation Specification: A Unified Computational Framework for Reasoning over Genomic Variant Categories.bioRxiv : the preprint server for biology · 2026Article
- iPepGen: a modular, immunopeptidogenomic analysis pipeline for discovery, verification, and prioritization of cancer peptide neoantigen candidates.Genome biology · 2026Article
- CancerStop.dev: an interactive web platform integrating prognostic data, clinical trials, and genomic resources for patient empowerment.Frontiers in digital health · 2026Article
- Availability of benign missense variant "truthsets" for validation of functional assays: Current status and a systematic approach.American journal of human genetics · 2025Article
- A New Era of Data-Driven Cancer Research and Care: Opportunities and Challenges.Cancer discovery · 2024Article
- CIViCdb 2022: evolution of an open-access cancer variant interpretation knowledgebase.Nucleic acids research · 2023Article
- Accessing clinical-grade genomic classification data through the ClinGen Data Platform.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
52 authors.
Kilannin Krysiak *Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. kkrysiak@wustl.edu.ORCID http://orcid.org/0000-0002-6299-9230
Arpad M Danos *McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-9815-2288
Susanna KiwalaMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Joshua F McMichaelMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0197-2245
Adam C CoffmanMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-0944-3126
Erica K BarnellMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Lana ShetaMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Jason SalibaMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Cameron J GrisdaleCanada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0003-1923-6972
Lynzey KujanMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Shahil PemaMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Jake LeverSchool of Computer Science, University of Glasgow, Glasgow, UK.
Nicholas C SpiesMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Andreea ChioreanDepartment of Medicine, Division of Medical Oncology, University Health Network, Toronto, Ontario, Canada.
Damian T RiekeCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Kaitlin A ClarkMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Payal JaniDepartment of Medicine, Division of Medical Oncology, University Health Network, Toronto, Ontario, Canada.
Hideaki TakahashiDepartment of Experimental Therapeutics/Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Peter HorakDepartment of Translational Medical Oncology, National Center for Tumor Diseases Heidelberg and German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-4536-9306
Deborah I RitterDepartment of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Xin ZhouDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Benjamin J AinscoughMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-8340-514X
Sean DelongLassonde School of Engineering, York University, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-0342-7862
Mario LampingCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Alex R MarrDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-1448-7353
Brian V LiMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Wan-Hsin LinMayo Clinic Florida, Jacksonville, FL, USA.
Panieh TerrafDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yasser SalamaDepartment of Medicine, Division of Medical Oncology, University Health Network, Toronto, Ontario, Canada.
Katie M CampbellMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-6491-4432
Kirsten M FarncombeToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Jianling JiChildren's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4941-3538
Xiaonan ZhaoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Xinjie XuDivision of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Rashmi Kanagal-ShamannaDepartment of Hematopathology and Molecular Diagnostics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0001-7829-5249
Kelsy C CottoMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-0890-6889
Zachary L SkidmoreMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.
Jason R WalkerMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-7547-5789
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0003-3350-9682
Aleksandar MilosavljevicDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Ronak Y PatelDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Rachel H GilesInternational Kidney Cancer Coalition, Amsterdam, the Netherlands.
Raymond H KimFred A. Litwin Family Centre in Genetic Medicine, Familial Cancer Clinic, Princess Margaret Cancer Centre, University Health Network, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Lynn M SchrimlUniversity of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-8910-9851
Elaine R MardisThe Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-5892-1553
Steven J M JonesCanada's Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0003-3394-2208
Gordana RacaChildren's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.
Shruti RaoInnovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA.
Subha MadhavanInnovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA.
Alex H WagnerThe Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA.
Obi L GriffithMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA. obigriffith@wustl.edu.ORCID http://orcid.org/0000-0002-0843-4271
Malachi GriffithMcDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA. mgriffit@wustl.edu.ORCID http://orcid.org/0000-0002-6388-446X
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MThe Clinical Genome Resource – Advancing genomic medicine through biocuration and expert assessment of genes and variants at scaleU24HG009650 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JONATHAN S BERG, Jessica Ezzell Hunter · 2021 to 2026
$30.0MThe Future of PharmGKB Funding Under NHGRIU41HG009649 · NHGRI · STANFORD UNIVERSITY · PI BUSTAMANTE, CARLOS DANIEL · 2017 to 2020
$13.4MStandardized and Genome-Wide Clinical Interpretation of Complex Genotypes for Cancer Precision MedicineU24CA237719 · NCI · WASHINGTON UNIVERSITY · PI GRIFFITH, OBI L. · 2019 to 2023
$3.8MThe Disease Ontology Project: mechanistic profiles of human disease for biomedical and clinical researchU41HG008735 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI SCHRIML, LYNN MARIE · 2017 to 2021
$3.4MIntegrated Analysis & Interpretation of Whole Genome Exome & Transcriptome SequenR00HG007940 · NHGRI · WASHINGTON UNIVERSITY · PI GRIFFITH, MALACHI · 2017 to 2019
$724kDEFINING THE REGULATORY, NON-CODING, MUTATIONAL LANDSCAPE OF BREAST CANCERK22CA188163 · NCI · WASHINGTON UNIVERSITY · PI GRIFFITH, OBI L. · 2014 to 2016
$515kTOOLS FOR NORMALIZING AND INTERPRETING THE CLINICAL ACTIONABILITY OF GENOMIC VARIANTSK99HG010157 · NHGRI · WASHINGTON UNIVERSITY · PI WAGNER, ALEX HANDLER · 2019 to 2020
$226kNCATS NIH HHS UL1 TR002345NCI NIH HHS K22 CA188163NCI NIH HHS U24 CA237719NHGRI NIH HHS K99 HG010157NHGRI NIH HHS R00 HG007940NHGRI NIH HHS U24 HG009650NHGRI NIH HHS U41 HG008735NHGRI NIH HHS U41 HG009649
Abstract
PubMed holds no abstract for this paper.
Indexed as
NeoplasmsGenetic VariationHumans
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.