ArticleNature immunology2022
Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation.
Erratum issuedOpen access · hybridAbstract read
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Article in Nature immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 57 papers.
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57citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
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Who cites it
57 citing papers in PubMed, 76 citations in OpenAlex.
- Monocytes in pneumonia: Functional plasticity and innate memory (Review).International journal of molecular medicine · 2026Review
- Hypoxia suppresses platelet activity through GPVI down-regulation but paradoxically enhances arterial thrombosis via elevated vWF.Cardiovascular research · 2026Article
- Cyclen Tetra-Amide Ligands as a Privileged Class of Ligands for Studying Second-Sphere Coordination Environments.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Targeting macrophage ferritin heavy chain mitigates ferroptosis and lung injury in experimental acute respiratory distress syndrome.Nature communications · 2026Article
- Immunosenescence in systemic and multi-organ aging: mechanisms, inter-organ crosstalk, and translational opportunities.npj aging · 2026Review
- Fibroblasts as regulators of lung immunity, repair and fibrosis.Nature reviews. Immunology · 2026Review
- Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes.The Journal of experimental medicine · 2026Article
- Erythropoietin exposure disrupts B cell development and drives the emergence of myeloid-biased biphenotypic progenitors.Stem cell reports · 2026Article
- High-Altitude Condition Induces Hepatic Magnetic Susceptibility Changes and Liver Injury.Biomolecules · 2026Article
- Roles of the Altitude-Adapted Immune Microenvironment in Pulmonary Vascular Remodeling in High-Altitude Pulmonary Hypertension: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Hypoxia-driven crosstalk among cardiac fibroblasts, macrophages, and endothelial cells in cardiac fibrosis.Frontiers in cell and developmental biology · 2026Review
- Lactylation modification - a bridge between sepsis and macrophage metabolic reprogramming.Frontiers in immunology · 2026Review
- Neutrophil Plasticity in Airway Disease: Balancing Damage and Repair.Journal of innate immunity · 2026Review
- Toll-like receptors in innate immunity and inflammation: from fundamental biology to clinic insights.Immunity & inflammation · 2026Review
- Multi-omics analysis reveals distinct spatial compartmentalization of lung repair niches in pediatric ARDS.Journal of translational medicine · 2025Article
- Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity.Nature immunology · 2025Article
- Distinct lung microbiota community states are associated with pulmonary nontuberculous mycobacterial disease prognosis.BMC microbiology · 2025Article
- Macrophage fatty acid metabolism under chronic hypoxia shapes γδ T cell recruitment via CCL22.iScience · 2025Article
- Hypoxia Exacerbates Inflammatory Signaling in Human Coronavirus OC43-Infected Lung Epithelial Cells.Biomolecules · 2025Article
- Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
42 authors at 10 institutions in 1 country.
Ananda S MirchandaniUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. Ananda.Mirchandani@ed.ac.uk.ORCID http://orcid.org/0000-0002-5492-1687
Stephen J Jenkins *University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0233-5424
Calum C Bain *University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-8884-327X
Manuel A Sanchez-GarciaUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Hannah LawsonBarts Cancer Institute, Queen Mary University of London, London, UK.
Patricia CoelhoUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Fiona MurphyUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
David M GriffithUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-9500-241X
Ailiang ZhangUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Tyler MorrisonUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Tony LyWellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Simone ArientiUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-5406-0012
Pranvera SadikuUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Emily R WattsUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Rebecca S DickinsonUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Leila ReyesUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
George CooperUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-3652-3837
Sarah ClarkIntensive Care Unit, Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK.
David LewisWellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Van KellyWellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Christos SpanosWellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
Kathryn M MusgraveTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Liam DelaneyUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-2894-1622
Isla HarperUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1736-2545
Jonathan ScottTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Nicholas J ParkinsonRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6336-5654
Anthony J RostronTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
J Kenneth BaillieWellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5258-793X
Sara ClohiseyRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-7489-9846
Clare PridansUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-9423-557X
Lara CampanaCentre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
Philip Starkey LewisCentre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
A John SimpsonTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
David H DockrellUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2718-4861
Jürgen SchwarzeUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Nikhil HiraniUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-8854-3605
Peter J RatcliffeNuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Christopher W PughNuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Kamil KrancBarts Cancer Institute, Queen Mary University of London, London, UK.
Stuart J ForbesUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-3715-2561
Moira K B WhyteUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-7788-1852
Sarah R WalmsleyUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-9584-174X
Queen's Medical Centre · GBWellcome Centre for Cell Biology · GBMRC Centre for Regenerative Medicine · GBNewcastle University · GBRoslin Institute · GBQueen Mary University of London · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GBNHS Lothian · GBNuffield Orthopaedic Centre · GBThe Francis Crick Institute · GB
Funding
Cancer Research UK 14633Cancer Research UK 26787Cancer Research UK C29967A/14633Cancer Research UK C29967/A26787Department of HealthMedical Research Council MR/N02995X/1Medical Research Council MR/P010008/1Medical Research Council MR/P010008/2Medical Research Council MR/P019935/1Medical Research Council MR/T029668/1Wellcome Trust 098516Wellcome Trust 110086Wellcome Trust 110086/Z/15/ZWellcome Trust 206211/Z/17/ZWellcome Trust 206234Wellcome Trust 209220Wellcome Trust 209220/Z/17/ZWellcome Trust PIII052
Abstract
Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia, and its impact on immune responses, is often neglected. In the present study, we have shown that ARDS patients were hypoxemic and monocytopenic within the first 48 h of ventilation. Monocytopenia was also observed in mouse models of hypoxic acute lung injury, in which hypoxemia drove the suppression of type I interferon signaling in the bone marrow. This impaired monopoiesis resulted in reduced accumulation of monocyte-derived macrophages and enhanced neutrophil-mediated inflammation in the lung. Administration of colony-stimulating factor 1 in mice with hypoxic lung injury rescued the monocytopenia, altered the phenotype of circulating monocytes, increased monocyte-derived macrophages in the lung and limited injury. Thus, tissue hypoxia altered the dynamics of the immune response to the detriment of the host and interventions to address the aberrant response offer new therapeutic strategies for ARDS.
Indexed as
Lung InjuryRespiratory Distress SyndromeAnimalsHumansHypoxiaInflammationLungMice
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.