ArticleScientific reports2022
Differences in composition of interdigital skin microbiota predict sheep and feet that develop footrot.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Seasonal Dynamics of Skin Microbiota and Metabolites in Transhumant-Grazed Altay Sheep.Microorganisms · 2026Article
- Application of 16S rRNA gene amplicon sequencing in the investigation of novel ovine skin lesions in Norway.Frontiers in veterinary science · 2026Article
- Variation in the early-life interdigital skin microbiota of lambs in a commercial sheep flock.Frontiers in veterinary science · 2026Article
- Molecular Diagnosis of Footrot and Contagious Ovine Digital Dermatitis in Small Ruminants in the Iberian Peninsula.Animals : an open access journal from MDPI · 2024Article
- When the host's away, the pathogen will play: the protective role of the skin microbiome during hibernation.Animal microbiome · 2023Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Footrot has a major impact on health and productivity of sheep worldwide. The current paradigm for footrot pathogenesis is that physical damage to the interdigital skin (IDS) facilitates invasion of the essential pathogen Dichelobacter nodosus. The composition of the IDS microbiota is different in healthy and diseased feet, so an alternative hypothesis is that changes in the IDS microbiota facilitate footrot. We investigated the composition and diversity of the IDS microbiota of ten sheep, five that did develop footrot and five that did not (healthy) at weekly intervals for 20 weeks. The IDS microbiota was less diverse on sheep 2 + weeks before they developed footrot than on healthy sheep. This change could be explained by only seven of > 2000 bacterial taxa detected. The incubation period of footrot is 8-10 days, and there was a further reduction in microbial diversity on feet that developed footrot in that incubation period. We conclude that there are two stages of dysbiosis in footrot: the first predisposes sheep to footrot and the second occurs in feet during the incubation of footrot. These findings represent a step change in our understanding of the role of the IDS microbiota in footrot pathogenesis.
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Registered trials
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