Evidence map›Paper›PMID 35624128›Full record

ArticleScientific reports2022

The value of histological examination in the diagnosis of tuberculous lymphadenitis in the era of rapid molecular diagnosis.

Sabira Tahseen, Atiqa Ambreen, Sheeba Ishtiaq, Faisal M Khanzada, Nauman Safdar, Lisbet Sviland, Tehmina Mustafa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

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  7. Observational
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  9. Histopathological features in the clinical specimens with tuberculosis diagnosis by BACTEC MGIT 960 culture.Journal of clinical tuberculosis and other mycobacterial diseases · 2023
    Article
  10. Efficacy of light chain 3-fused protein multi epitope in protection of mice challenged withVeterinary research forum : an international quarterly journal · 2023
    Article
  11. Article
  12. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sabira TahseenDepartment of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway. sabira.tahseen@gmail.com.
Atiqa AmbreenDepartment of Microbiology, Gulab Devi Hospital, Lahore, Pakistan.
Sheeba IshtiaqDepartment of Pathology, Gulab Devi Hospital, Lahore, Pakistan.
Faisal M KhanzadaNational TB Reference Laboratory, National Tuberculosis Control Program Pakistan, Block E and F, EPI building, Near NIH, Chak Shahzad, Islamabad, Pakistan.
Nauman SafdarDepartment of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway.
Lisbet SvilandDepartment of Clinical Medicine, Faculty of Medicine, University of Bergen, Bergen, Norway.
Tehmina MustafaDepartment of Global Public Health and Primary Care, Centre for International Health, University of Bergen, Bergen, Norway.
Haukeland University Hospital · NOAga Khan Development Network · PKUniversity of Bergen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extrapulmonary tuberculosis often poses a diagnostic challenge. This study aimed to assess the value of histological examination in diagnosing tuberculous lymphadenitis (LNTB) when performed simultaneously with rapid molecular assay (Xpert MTB/RIF) testing. People presumed to have LNTB were prospectively enrolled in a tertiary care hospital. Excision biopsy was performed and tested by histology, Xpert, and culture. Of 390 lymph nodes, 11 (2.8%) were positive by AFB microscopy, 124 (31.8%) by Xpert, 137 (35.1%) by culture, and histopathology was consistent with TB in 208 (53.3%). Altogether, LNTB was diagnosed in 228 and bacteriologically confirmed TB in 178 cases. Against culture, histopathology versus Xpert had higher sensitivity (93 vs. 62%) but lower specificity (68 vs. 83%). In patients with short clinical history, a significantly higher number of Xpert-positive specimens were culture-positive. Among patients with histology suggestive of TB, no difference was seen in response to treatment between bacteriology positive and negative, but a significant slow response was noted in bacteriology confirmed TB with nonspecific histology. In a country like Pakistan, with high TB and low HIV prevalence, diagnosis is possible for more than 95% of LNTB when Xpert and histopathology examination is used in combination, compared to less than 60% by Xpert alone.

Indexed as

LymphadenitisMycobacterium tuberculosisTuberculosis, Lymph NodeHistological TechniquesHumansLymph Nodes

Identifiers

PMID35624128
PMCPMC9142592
OpenAlexW4281721540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.