ArticleNature communications2022
Cross-reactive immunity against the SARS-CoV-2 Omicron variant is low in pediatric patients with prior COVID-19 or MIS-C.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Duration of immunity to SARS-CoV-2 in children after natural infection or vaccination in the omicron and pre-omicron era: A systematic review of clinical and immunological studies.Frontiers in immunology · 2022Pooled it
- A Bivalent Omicron-Containing Booster Vaccine against Covid-19.The New England journal of medicine · 2022Trial
- SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children.Nature communications · 2026Article
- SARS-CoV-2 infection and vaccination elicit distinct pharyngeal mucosal B cell responses in children.Research square · 2025Article
- Prior SARS-CoV-2 infection affects adaptive immune responses to Omicron BA.4/BA.5 mRNA booster.The Journal of allergy and clinical immunology · 2025Article
- Next generation sequencing of multiple SARS-CoV-2 infections in the Omicron Era.Scientific reports · 2025Article
- The Incidence and Clinical Characteristics of COVID-19 in Children With IBD During the Omicron Wave: A Single-Center Experience in China.Gastroenterology research and practice · 2025Article
- Evolution of the Antigenic Landscape in Children and Young Adults with COVID-19 and MIS-C.Vaccines · 2024Article
- Timing of general anesthesia for pediatric patients recovering from COVID-19: a prospective cohort study.BMC anesthesiology · 2024Article
- Humoral and cellular immune responses in vaccinated and unvaccinated children following SARS-CoV-2 Omicron infection.Clinical & translational immunology · 2024Article
- Neutralization of SARS-CoV-2 Omicron BQ.1, BQ.1.1 and XBB.1 variants following SARS-CoV-2 infection or vaccination in children.Nature communications · 2023Article
- Susceptibility of bovine to SARS-CoV-2 variants of concern: insights from ACE2, AXL, and NRP1 receptors.Virology journal · 2023Article
- Infection and Vaccine Induced Spike Antibody Responses Against SARS-CoV-2 Variants of Concern in COVID-19-Naïve Children and Adults.Journal of clinical immunology · 2023Article
- Article
- Multisystem inflammatory syndrome in children (MIS-C): Implications for long COVID.Inflammopharmacology · 2023Review
- Immunological imprinting of humoral immunity to SARS-CoV-2 in children.Nature communications · 2023Article
- Article
- Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine.Science translational medicine · 2023Article
- Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Antibody Responses After Community Infections in Children and Adults.Open forum infectious diseases · 2023Article
- Impact of hybrid immunity booster vaccination and Omicron breakthrough infection on SARS-CoV-2 VOCs cross-neutralization.iScience · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
39 authors at 20 institutions in 1 country.
Juanjie Tang *Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.
Tanya Novak *Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0002-7115-7545
Julian Hecker *Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Gabrielle Grubbs *Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.ORCID http://orcid.org/0000-0003-4302-9535
Fatema Tuz ZahraDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.
Lorenza BellusciDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.
Sara PourhashemiDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA.
Janet ChouDepartment of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Kristin MoffittDepartment of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Natasha B HalasaDivision of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Stephanie P SchwartzDepartment of Pediatrics, University of North Carolina at Chapel Hill Children's Hospital, Chapel Hill, NC, 27514, USA.
Tracie C WalkerDepartment of Pediatrics, University of North Carolina at Chapel Hill Children's Hospital, Chapel Hill, NC, 27514, USA.
Keiko M TarquinioDivision of Critical Care Medicine, Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA, 30322, USA.
Matt S ZinterDepartment of Pediatrics, Divisions of Critical Care and Bone Marrow Transplantation, University of California, San Francisco, San Francisco, CA, 94158, USA.ORCID http://orcid.org/0000-0003-3351-3278
Mary A StaatDepartment of Pediatrics, University of Cincinnati, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Shira J GertzDivision of Pediatric Critical Care, Department of Pediatrics, Cooperman Barnabas Medical Center, Livingston, NJ, 07039, USA.
Natalie Z CvijanovichDivision of Critical Care Medicine, UCSF Benioff Children's Hospital Oakland, Oakland, CA, 94609, USA.
Jennifer E SchusterDivision of Pediatric Infectious Diseases, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MO, 64108, USA.
Laura L LoftisDivision of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX, 77030, USA.
Bria M CoatesDivision of Critical Care Medicine, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.
Elizabeth H MackDivision of Pediatric Critical Care Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.
Katherine IrbySection of Pediatric Critical Care, Department of Pediatrics, Arkansas Children's Hospital, Little Rock, AR, 72202, USA.ORCID http://orcid.org/0000-0001-8111-3215
Julie C FitzgeraldDivision of Critical Care, Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Courtney M RowanDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN, 46202, USA.ORCID http://orcid.org/0000-0003-1393-6476
Michele KongDivision of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
Heidi R FloriDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Mott Children's Hospital and University of Michigan, Ann Arbor, MI, 48109, USA.
Aline B MadduxDepartment of Pediatrics, Section of Critical Care Medicine, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, 80045, USA.
Steven L SheinDivision of Pediatric Critical Care Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, 44106, USA.ORCID http://orcid.org/0000-0003-3382-5159
Hillary CrandallDivision of Pediatric Critical Care, Department of Pediatrics, University of Utah, Salt Lake City, UT, 84113, USA.ORCID http://orcid.org/0000-0002-5392-8457
Janet R HumeDivision of Pediatric Critical Care, University of Minnesota Masonic Children's Hospital, Minneapolis, MN, 55454, USA.
Charlotte V HobbsDepartment of Pediatrics, Department of Microbiology, Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS, 39202, USA.
Adriana H TremouletKawasaki Disease Research Center, Rady Children's Hospital and Department of Pediatrics, UCSD School of Medicine, La Jolla, CA, 92093, USA.
Chisato ShimizuKawasaki Disease Research Center, Rady Children's Hospital and Department of Pediatrics, UCSD School of Medicine, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0002-3149-2699
Jane C BurnsKawasaki Disease Research Center, Rady Children's Hospital and Department of Pediatrics, UCSD School of Medicine, La Jolla, CA, 92093, USA.
Sabrina R ChenDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Hye Kyung MoonDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Christoph LangeDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Adrienne G RandolphDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0002-3084-3071
Surender KhuranaDivision of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA, Silver Spring, MD, 20993, USA. Surender.Khurana@fda.hhs.gov.ORCID http://orcid.org/0000-0002-0593-7965
Boston Children's Hospital · USCenter for Biologics Evaluation and Research · USRady Children's Hospital-San Diego · USUniversity of North Carolina at Chapel Hill · USArkansas Children's Hospital · USBaylor College of Medicine · USBrigham and Women's Hospital · USChildren's Hospital Colorado · USChildren's Mercy Hospital · USCincinnati Children's Hospital Medical Center · USEmory University · USHarvard University · USMedical University of South Carolina · USNorthwestern University · USRainbow Babies & Children's Hospital · USRiley Hospital for Children · USSaint Barnabas Medical Center · USUCSF Benioff Children's Hospital · USUniversity of Alabama at Birmingham · USUniversity of California, San Francisco · US
Funding
Genetic Epidemiology of Life-Threatening Influenza in ChildrenR01AI084011 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI RANDOLPH, ADRIENNE G · 2010 to 2013
$3.1MPathobiologic Transcriptional Signatures of Pulmonary Complications in Pediatric Hematopoietic Cellular TransplantationK23HL146936 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZINTER, MATTHEW SCOTT · 2020 to 2024
$980kPrognostic biomarkers for respiratory failure post hematopoietic cell transplantationK23HL150244 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI ROWAN, COURTNEY · 2020 to 2024
$899kFunctional Outcomes after Prolonged Mechanical Ventilation in ChildrenK23HD096018 · NICHD · UNIVERSITY OF COLORADO DENVER · PI MADDUX, ALINE BERNARD · 2019 to 2023
$807kNHLBI NIH HHS K23 HL146936NHLBI NIH HHS K23 HL150244NIAID NIH HHS R01 AI084011NICHD NIH HHS K23 HD096018
Abstract
Neutralization capacity of antibodies against Omicron after a prior SARS-CoV-2 infection in children and adolescents is not well studied. Therefore, we evaluated virus-neutralizing capacity against SARS-CoV-2 Alpha, Beta, Gamma, Delta and Omicron variants by age-stratified analyses (<5, 5-11, 12-21 years) in 177 pediatric patients hospitalized with severe acute COVID-19, acute MIS-C, and in convalescent samples of outpatients with mild COVID-19 during 2020 and early 2021. Across all patients, less than 10% show neutralizing antibody titers against Omicron. Children <5 years of age hospitalized with severe acute COVID-19 have lower neutralizing antibodies to SARS-CoV-2 variants compared with patients >5 years of age. As expected, convalescent pediatric COVID-19 and MIS-C cohorts demonstrate higher neutralization titers than hospitalized acute COVID-19 patients. Overall, children and adolescents show some loss of cross-neutralization against all variants, with the most pronounced loss against Omicron. In contrast to SARS-CoV-2 infection, children vaccinated twice demonstrated higher titers against Alpha, Beta, Gamma, Delta and Omicron. These findings can influence transmission, re-infection and the clinical disease outcome from emerging SARS-CoV-2 variants and supports the need for vaccination in children.
Indexed as
COVID-19SARS-CoV-2AdolescentAntibodies, ViralChildChild, PreschoolHumansMembrane GlycoproteinsNeutralization TestsSpike Glycoprotein, CoronavirusSystemic Inflammatory Response SyndromeViral Envelope ProteinsAntibodies, ViralMembrane GlycoproteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Viral Envelope Proteins
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