Evidence map›Paper›PMID 35623855›Full record

Observational studyClinical nutrition ESPEN2022

Iron status and inflammation in women of reproductive age: A population-based biomarker survey and clinical study.

Julia L Finkelstein, Amy Fothergill, Heather M Guetterman, Christina B Johnson, Beena Bose, Yan Ping Qi, Charles E Rose, Jennifer L Williams, Saurabh Mehta, Rebecca Kuriyan and 2 more

2 registry-linked trialsOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical nutrition ESPEN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03853304 naunknown statusnot on this mapstarted 2023, after this paper: background citation

A Randomized Trial of Quadruple Fortified Salt for Anemia and Birth Defects Prevention in Southern India

TypeinterventionalSponsorCornell UniversityRan2023 to 2024Enrolled1,000ConditionsAnemia, Folate Deficiency, Vitamin B 12 DeficiencyArms+ Folic acid, + Vitamin B12, DFS
NCT04048330 unknown statusnot on this map

Periconceptional Surveillance for Prevention of Anemia and Birth Defects in India

TypeobservationalSponsorCornell UniversityRan2018 to 2024Enrolled2,000ConditionsAnemia, Folate Deficiency, Vitamin B12 Deficiency
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Vitamin BClinical nutrition ESPEN · 2025
    Observational
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Julia L FinkelsteinDivision of Nutritional Sciences, Cornell University, Ithaca NY, USA; Division of Epidemiology, Department of Population Health Sciences, Weill Cornell Medical College, New York, NY, USA; Institute for Nutritional Sciences, Global Health, and Technology, Cornell University, Ithaca, NY, USA; St. John's Research Institute, Bangalore, Karnataka, India. Electronic address: jfinkelstein@cornell.edu.
Amy FothergillDivision of Nutritional Sciences, Cornell University, Ithaca NY, USA.
Heather M GuettermanDivision of Nutritional Sciences, Cornell University, Ithaca NY, USA.
Christina B JohnsonArogyavaram Medical Centre, Andhra Pradesh, India.
Beena BoseSt. John's Research Institute, Bangalore, Karnataka, India.
Yan Ping QiNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Charles E RoseNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Jennifer L WilliamsNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Saurabh MehtaDivision of Nutritional Sciences, Cornell University, Ithaca NY, USA; Division of Epidemiology, Department of Population Health Sciences, Weill Cornell Medical College, New York, NY, USA; Institute for Nutritional Sciences, Global Health, and Technology, Cornell University, Ithaca, NY, USA.
Rebecca KuriyanSt. John's Research Institute, Bangalore, Karnataka, India.
Wesley BonamArogyavaram Medical Centre, Andhra Pradesh, India.
Krista S CriderNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Centers for Disease Control and Prevention · USCornell University · USSt.John's Medical College Hospital · IN

Funding

Coordinating Center for Research and Training to Promote the Health of People witU01DD001007 · DD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI CARLIN, ROBERTA, MCDERMOTT, SUZANNE W · 2012 to 2016
$13.1M
NUTRITION TRAININGT32DK007158 · NIDDK · CORNELL UNIVERSITY ITHACA · PI PATRICIA A CASSANO, Julia L. Finkelstein · 1986 to 2026
$7.4M
TRAINING IN MATERNAL AND CHILD NUTRITIONT32HD087137 · NICHD · CORNELL UNIVERSITY · PI Laura Bellows, Julia L. Finkelstein · 2016 to 2026
$2.0M
ACL HHS U01DD001007NCBDD CDC HHS U01 DD001007NCBDD CDC HHS U19 DD001218NICHD NIH HHS T32 HD087137NIDDK NIH HHS T32 DK007158
6 · The paper itself

Abstract

backgroundWomen of reproductive age (WRA) are at increased risk for anemia and iron deficiency. However, there is limited population-level data in India, which could help inform evidence-based recommendations and policy.

aimsTo conduct a population-based biomarker survey of anemia, iron deficiency, and inflammation in WRA in Southern India.

methodsParticipants were WRA (15-40 y) who were not pregnant or lactating. Blood samples (n = 979) were collected and analyzed for hemoglobin (Hb), serum ferritin (SF), soluble transferrin receptor (sTfR), C-reactive protein (CRP), and alpha-1 acid glycoprotein (AGP). Anemia and severe anemia were defined as Hb < 12.0 and < 8.0 g/dL. Serum ferritin was adjusted for inflammation using BRINDA methods. Iron deficiency was defined as SF <15.0 μg/L, iron insufficiency was defined as SF < 20.0 and < 25.0 μg/L, and iron deficiency anemia was defined as Hb < 12.0 g/dL and SF < 15.0 μg/L. Inflammation was defined as CRP > 5.0 mg/L or AGP > 1.0 g/L. Restricted cubic spline regression models were also used to determine if alternative SF thresholds should be used t to classify iron deficiency.

resultsA total of 41.5% of WRA had anemia, and 3.0% had severe anemia. Findings from spline analyses suggested a SF cut-off of < 15.0 μg/L, consistent with conventional cut-offs for iron deficiency. 46.3% of WRA had SF < 15.0 μg/L (BRINDA-adjusted: 61.5%), 55.0% had SF < 20.0 μg/L (72.7%), 61.8% had SF < 25.0 μg/L (81.0%), and 30.0% had IDA (34.5%). 17.3% of WRA had CRP > 5.0 mg/L and 22.2% had AGP > 1.0 g/L. The prevalence of ID (rural vs. urban: 49.1% vs. 34.9%; p = 0.0004), iron insufficiency (57.8% vs. 43.8%; p = 0.0005), and IDA (31.8% vs. 22.4%; p = 0.01) were significantly higher in rural areas, although CRP levels were lower and there were no differences in elevated CRP or AGP.

conclusionsThe burden of anemia and iron deficiency in this population was substantial, and increased after adjusting for inflammation, suggesting potential to benefit from screening and interventions. REGISTRATION NUMBER: NCT04048330.

Indexed as

AnemiaIron DeficienciesAdolescentAdultBiomarkersC-Reactive ProteinFemaleFerritinsHemoglobinsHumansInflammationIronLactationPregnancyYoung AdultBiomarkersC-Reactive ProteinFerritinsHemoglobinsIronAnemiaIndiaInflammationIron statusPericonceptionalWoman of reproductive age

Identifiers

PMID35623855
PMCPMC10878764
OpenAlexW4220891198

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.