ArticlePharmacoepidemiology and drug safety2022
Identification of pregnancies and infants within a US commercial healthcare administrative claims database.
Article in Pharmacoepidemiology and drug safety, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Developing a Hierarchical Algorithm to Identify Pregnancies and Determine Gestational Age from Nationwide Linked Health Data in Taiwan.Drug safety · 2026Article
- Identifying Pregnancies in Population-Based Data Sources: Development and Application of the ConcePTION Pregnancy Algorithm.Pharmacoepidemiology and drug safety · 2026Article
- PregMedNet: Multifaceted maternal medication impacts on neonatal complications.Nature communications · 2026Article
- Risk of Fetal Exposure to Teratogenic Medications: Development of Evidence for the Teratogenic Risk Impact and Mitigation (TRIM) Tool.Drug safety · 2026Article
- Pregnancy identification method as a source of bias in studies of prenatal exposures using real-world data.American journal of epidemiology · 2026Article
- Identifying pregnancies in routinely collected health data: a scoping review of methods.BMC medical informatics and decision making · 2026Article
- Evaluation of gestational age by pregnancy outcomes and distribution of pregnancy-related codes in Korean claims data.Epidemiology and health · 2026Article
- Linking deliveries to newborns using nationwide Medicaid data.BMC medical research methodology · 2025Article
- PregMedNet: Multifaceted Maternal Medication Impacts on Neonatal Complications.medRxiv : the preprint server for health sciences · 2025Article
- Development of a Pregnancy Cohort in Commercial Insurance Claims Data: Evaluation of Deliveries Identified From Inpatient Versus Outpatient Claims.Pharmacoepidemiology and drug safety · 2025Article
- Linking household members and defining relational networks using routine health data.Current opinion in pediatrics · 2025Review
- Severe Maternal Morbidity Among Pregnant People With Opioid Use Disorder Enrolled in Medicaid.JAMA network open · 2025Article
- Use of the Sentinel System to Examine Medical Product Use and Outcomes During Pregnancy.Drug safety · 2024Review
- Real-world data are not always big data: the case for primary data collection on medication use in pregnancy in the context of birth defects research.American journal of epidemiology · 2024Article
- Association of Traditional and Nontraditional Risk Factors in the Development of Strokes Among Young Adults by Sex and Age Group: A Retrospective Case-Control Study.Circulation. Cardiovascular quality and outcomes · 2024Article
- Defining, measuring, and evaluating prenatal care in insurance claims data.Current epidemiology reports · 2024Article
- Development and evaluation of an algorithm to link mothers and infants in two US commercial healthcare claims databases for pharmacoepidemiology research.BMC medical research methodology · 2023Article
- Who is pregnant? Defining real-world data-based pregnancy episodes in the National COVID Cohort Collaborative (N3C).JAMIA open · 2023Article
- Duration of medication for opioid use disorder during pregnancy and postpartum by race/ethnicity: Results from 6 state Medicaid programs.Drug and alcohol dependence · 2023Article
- Changes in Medication Use During Pregnancy for Women with Chronic Conditions: An Analysis of Claims Data.Therapeutic innovation & regulatory science · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHealth care insurance claims databases are becoming a more common data source for studies of medication safety during pregnancy. While pregnancies have historically been identified in such databases by pregnancy outcomes, International Classification of Diseases, 10th revision Clinical Modification (ICD-10-CM) Z3A codes denoting weeks of gestation provide more granular information on pregnancies and pregnancy periods (i.e., start and end dates). The purpose of this study was to develop a process that uses Z3A codes to identify pregnancies, pregnancy periods, and links infants within a commercial health insurance claims database.
methodsWe identified pregnancies, gestation periods, pregnancy outcomes, and linked infants within the US-based Optum Research Database between 2015 and 2020 via a series of algorithms utilizing diagnosis and procedure codes on claims. The diagnosis and procedure codes included ICD-10-CM codes, Current Procedural Terminology (CPT) codes, and Healthcare Common Procedure Coding System (HCPCS) codes.
resultsWe identified 1 030 874 pregnancies among 841 196 women of reproductive age. Of pregnancies with livebirth outcomes, 84% were successfully linked to infants. The prevalence of pregnancy outcomes (livebirth, stillbirth, ectopic, molar, and abortion) was similar to national estimates.
conclusionsThis process provides an opportunity to study drug safety and care patterns during pregnancy and may be replicated in other claims databases containing ICD-10-CM, CPT, and HCPCS codes. Work is underway to validate and refine the various algorithms.
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