ArticleTropical medicine and infectious disease2022
Rickettsial Infections Are Neglected Causes of Acute Febrile Illness in Teluk Intan, Peninsular Malaysia.
Article in Tropical medicine and infectious disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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13 citing papers in PubMed, 13 citations in OpenAlex.
- Neglected rickettsial diseases in Southeast Asia: Twenty-five years of progress in surveillance, diagnostics, and clinical research.PLoS neglected tropical diseases · 2026Review
- Tick-host associations across contrasting habitats in tropical Peninsular Malaysia.Parasites & vectors · 2026Article
- Preliminary molecular detection and characterization ofOne health (Amsterdam, Netherlands) · 2025Article
- Genotype Analysis onTropical medicine and infectious disease · 2025Article
- Severe Scrub Typhus with Acute Kidney Injury: Urine PCR Evidence from an East Coast Malaysian Cluster.Tropical medicine and infectious disease · 2025Article
- Rickettsioses Seropositivity in Malaysia: A Six-Year Trend, 2016-2021.Tropical medicine and infectious disease · 2025Article
- Clinical Manifestations, Risk Factors, and Disease Burden of Rickettsiosis, Cambodia, 2007-2020.Emerging infectious diseases · 2025Review
- Complete mitochondrial genome sequence ofVeterinary research forum : an international quarterly journal · 2025Article
- From fever to action: diagnosis, treatment, and prevention of acute undifferentiated febrile illnesses.Pathogens and disease · 2024Review
- Comprehensive diagnostic testing identifies diverse aetiologies of acute febrile illness among hospitalised children and adults in Sri Lanka: a prospective cohort study.BMJ public health · 2023Article
- A Review of Rickettsial Diseases Other Than Scrub Typhus in India.Tropical medicine and infectious disease · 2023Review
- Habitat and Season Drive Chigger Mite Diversity and Abundance on Small Mammals in Peninsular Malaysia.Pathogens (Basel, Switzerland) · 2022Article
- Correction: Yuhana et al. Rickettsial Infections Are Neglected Causes of Acute Febrile Illness in Teluk Intan, Peninsular Malaysia.Tropical medicine and infectious disease · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 4 countries.
Funding
Abstract
Rickettsial infections are among the leading etiologies of acute febrile illness in Southeast Asia. However, recent data from Malaysia are limited. This prospective study was conducted in Teluk Intan, Peninsular Malaysia, during January to December 2016. We recruited 309 hospitalized adult patients with acute febrile illness. Clinical and biochemistry data were obtained, and patients were stratified into mild and severe infections based on the sepsis-related organ failure (qSOFA) scoring system. Diagnostic assays including blood cultures, real-time PCR, and serology (IFA and MAT) were performed. In this study, pathogens were identified in 214 (69%) patients, of which 199 (93%) patients had a single etiology, and 15 (5%) patients had >1 etiologies. The top three causes of febrile illness requiring hospitalization in this Malaysian study were leptospirosis (68 (32%)), dengue (58 (27%)), and rickettsioses (42 (19%)). Fifty-five (18%) patients presented with severe disease with a qSOFA score of ≥2. Mortality was documented in 38 (12%) patients, with the highest seen in leptospirosis (16 (42%)) followed by rickettsiosis (4 (11%)). While the significance of leptospirosis and dengue are recognized, the impact of rickettsial infections in Peninsular Malaysia remains under appreciated. Management guidelines for in-patient care with acute febrile illness in Peninsular Malaysia are needed.
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