Evidence map›Paper›PMID 35622691›Full record

ReviewTropical medicine and infectious disease2022

2.5 Million Annual Deaths-Are Neonates in Low- and Middle-Income Countries Too Small to Be Seen? A Bottom-Up Overview on Neonatal Morbi-Mortality.

Flavia Rosa-Mangeret, Anne-Caroline Benski, Anne Golaz, Persis Z Zala, Michiko Kyokan, Noémie Wagner, Lulu M Muhe, Riccardo E Pfister

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Tropical medicine and infectious disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Impact of the WHO safe childbirth checklist on birth attendant behavior and maternal-newborn outcomes: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Flavia Rosa-MangeretNeonatal Division, Geneva University Hospitals, 1205 Geneva, Switzerland.ORCID 0000-0003-0908-6237
Anne-Caroline BenskiObstetrics Division, Geneva University Hospitals, 1205 Geneva, Switzerland.
Anne GolazCenter for Education and Research in Humanitarian Action, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland.
Persis Z ZalaNeonatal Division, Geneva University Hospitals, 1205 Geneva, Switzerland.
Michiko KyokanGlobal Health Institute, University of Geneva, 1205 Geneva, Switzerland.
Noémie WagnerPediatric Infectious Diseases Division, Geneva University Hospitals, 1205 Geneva, Switzerland.
Lulu M MuheCollege of Health Sciences, Addis Ababa University, Addis Ababa 1000, Ethiopia.ORCID 0000-0002-2776-9923
Riccardo E PfisterNeonatal Division, Geneva University Hospitals, 1205 Geneva, Switzerland.ORCID 0000-0002-7395-0512

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Every year, 2.5 million neonates die, mostly in low- and middle-income countries (LMIC), in total disregard of their fundamental human rights. Many of these deaths are preventable. For decades, the leading causes of neonatal mortality (prematurity, perinatal hypoxia, and infection) have been known, so why does neonatal mortality fail to diminish effectively? A bottom-up understanding of neonatal morbi-mortality and neonatal rights is essential to achieve adequate progress, and so is increased visibility. (2) Methods: We performed an overview on the leading causes of neonatal morbi-mortality and analyzed the key interventions to reduce it with a bottom-up approach: from the clinician in the field to the policy maker. (3) Results and Conclusions: Overall, more than half of neonatal deaths in LMIC are avoidable through established and well-known cost-effective interventions, good quality antenatal and intrapartum care, neonatal resuscitation, thermal care, nasal CPAP, infection control and prevention, and antibiotic stewardship. Implementing these requires education and training, particularly at the bottom of the healthcare pyramid, and advocacy at the highest levels of government for health policies supporting better newborn care. Moreover, to plan and follow interventions, better-quality data are paramount. For healthcare developments and improvement, neonates must be acknowledged as humans entitled to rights and freedoms, as stipulated by international law. Most importantly, they deserve more respectful care.

Indexed as

neonatal morbidityneonatal mortalityneonatal rights

Identifiers

PMID35622691
PMCPMC9148074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.