Evidence map›Paper›PMID 35622648›Full record

ReviewToxics2022

Toxicological Effects of Technical Xylene Mixtures on the Female Reproductive System: A Systematic Review.

Noor Asyikin Suaidi, Mohammed Abdullah Alshawsh, See-Ziau Hoe, Mohd Helmy Mokhtar, Siti Rosmani Md Zin

Open access · goldAbstract readReview
In one paragraph

Review in Toxics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Histological Processing of Scaffolds: Challenges and Solutions.Journal of functional biomaterials · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Noor Asyikin SuaidiDepartment of Anatomy, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0002-6898-1007
Mohammed Abdullah AlshawshDepartment of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0001-8342-5183
See-Ziau HoeDepartment of Physiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0001-6138-1271
Mohd Helmy MokhtarDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-7801-6358
Siti Rosmani Md ZinDepartment of Anatomy, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0002-4114-8664
University of Malaya · MYNational University of Malaysia · MY

Funding

Ministry of Higher Education FRGS - FP113-2020.
6 · The paper itself

Abstract

Technical xylene is a compound of massive production that is used in applications such as petrochemical and healthcare laboratories. Exposure to xylene can cause acute and chronic effects in humans and animals. Currently available studies regarding xylene's adverse effects with credible designs were dated almost twenty years ago. This systematic review summarizes the findings regarding the detrimental effects of technical xylene from human, animal, and in vitro studies. It recapitulated available studies with respect to the effects of xylene on the female reproductive system to stress the need for updating the current data and guidelines. Based on pre-specified criteria, 22 studies from journal databases exploring the toxic effects of xylene on menstruation, endocrine endpoints, fetal development, and reproductive functions were included for the review. It was found that related studies with a specific focus on the effects of technical xylene on the female reproductive system were insufficient. Therefore, further studies are necessary to update the existing data, thus improving the quality and reliability of risk assessment of exposure to xylene in pregnant women.

Indexed as

endocrine disruptionfemale reproductive systemovarian toxicityreproductive toxicityxylene

Identifiers

PMID35622648
PMCPMC9144477
OpenAlexW4228998488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.