ReviewToxics2022
IVIVE: Facilitating the Use of
Open access · goldAbstract readReview
In one paragraph
Review in Toxics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
15.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 112 citations in OpenAlex.
- Chemical Distribution Kinetics of Five Polycyclic Aromatic Hydrocarbons in a Microphysiological System.Toxics · 2026Article
- From bench to bedside: Overcoming translational hurdles in nanoparticle research with pharmacokinetic modeling.Bioengineering & translational medicine · 2026Review
- Complex Distribution Phenomena and Plastic Binding of Test Chemicals in Cell Culture Experiments: Exemplification by Tebufenpyrad.International journal of molecular sciences · 2026Article
- An Integrated AIVIVE-PBPK-QIVIVE Framework with HTTK Validation for Probabilistic Risk Assessment of Neodymium Nitrate.Chemical research in toxicology · 2026Article
- Extrapolation of in vitro effect concentrations to in vivo bioavailable concentrations using PBK modelling in humans for two classes of persistent and mobile compounds: triazoles and triazines.Archives of toxicology · 2026Article
- The way forward for assessing the human health safety of cosmetics in the EU: Proceedings of Workshop 2.Archives of toxicology · 2026Article
- Perspective on applicability of data-driven machine learning computational new approach methodologies for hazard identification in chemicals risk assessment.Journal of cheminformatics · 2026Review
- Human Organoids and Organ-on-Chip for Biotoxin Assessment: Applications, Best Practices, and a Translational Roadmap.Toxins · 2026Review
- Application of in vitro to in vivo extrapolation (IVIVE) to inform chemical health guidance value derivation-sample case studies comparing neuro-, hepato-, and developmental toxicities.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Hypothesis-driven approach to developmental toxicity assessment: Using mechanistic information to inform testing.Reproductive toxicology (Elmsford, N.Y.) · 2026Review
- An in vitro-in silico workflow for predicting renal clearance of environmental chemicals and drugs.Toxicology · 2026Article
- Application ofFrontiers in toxicology · 2026Review
- AI snake oil? A risk/benefit analysis for toxicology.Frontiers in artificial intelligence · 2026Article
- Extrapolation steps in quantitativeCurrent research in toxicology · 2026Review
- Human biomonitoring of mycotoxins: key challenges and future directions.Mycotoxin research · 2025Review
- Industrial and agricultural chemicals exhibit antimicrobial activity against human gut bacteria in vitro.Nature microbiology · 2025Article
- Scientific Opinion on the application of physiologically based kinetic (PBK) modelling for the quantitative in vitro to in vivo extrapolation (QIVIVE) of developmental neurotoxicity in vitro battery (DNT IVB) data for pesticide active substances.EFSA journal. European Food Safety Authority · 2025Article
- The OASIS Consortium: integrating multi-omics technologies to transform chemical safety assessment.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Advances in Cytotoxicity Testing: From In Vitro Assays to In Silico Models.International journal of molecular sciences · 2025Review
- Synergistic toxicity in alcohol-associated liver disease and PFAS exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 13 institutions in 2 countries.
Xiaoqing ChangInotiv-RTP, 601 Keystone Park Drive, Suite 200, Morrisville, NC 27560, USA.ORCID 0000-0003-0752-1848
Yu-Mei TanU.S. Environmental Protection Agency, Office of Pesticide Programs, 109 T.W. Alexander Drive, Durham, NC 27709, USA.
David G AllenInotiv-RTP, 601 Keystone Park Drive, Suite 200, Morrisville, NC 27560, USA.ORCID 0000-0002-8575-9547
Shannon BellInotiv-RTP, 601 Keystone Park Drive, Suite 200, Morrisville, NC 27560, USA.ORCID 0000-0002-5754-6085
Paul C BrownU.S. Food and Drug Administration, Center for Drug Evaluation and Research, 10903 New Hampshire Avenue, Silver Spring, MD 20903, USA.
Lauren BrowningInotiv-RTP, 601 Keystone Park Drive, Suite 200, Morrisville, NC 27560, USA.
Patricia CegerInotiv-RTP, 601 Keystone Park Drive, Suite 200, Morrisville, NC 27560, USA.ORCID 0000-0002-5167-9928
Jeffery GearhartThe Henry M. Jackson Foundation, Air Force Research Laboratory, 711 Human Performance Wing, Wright-Patterson Air Force Base, OH 45433, USA.
Pertti J HakkinenNational Library of Medicine, National Center for Biotechnology Information, 8600 Rockville Pike, Bethesda, MD 20894, USA.ORCID 0000-0002-8295-9738
Shruti V KabadiU.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Food Additive Safety, 5001 Campus Drive, HFS-275, College Park, MD 20740, USA.
Nicole C KleinstreuerNational Institute of Environmental Health Sciences, National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, P.O. Box 12233, Research Triangle Park, NC 27709, USA.ORCID 0000-0002-7914-3682
Annie LumenU.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA.
Joanna MathesonU.S. Consumer Product Safety Commission, Division of Toxicology and Risk Assessment, 5 Research Place, Rockville, MD 20850, USA.ORCID 0000-0002-9912-0322
Alicia PainiEuropean Commission, Joint Research Centre (JRC), 21027 Ispra, Italy.ORCID 0000-0002-0669-1872
Heather A PangburnAir Force Research Laboratory, 711 Human Performance Wing, 2729 R Street, Area B, Building 837, Wright-Patterson Air Force Base, OH 45433, USA.
Elijah J PetersenU.S. Department of Commerce, National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, MD 20899, USA.ORCID 0000-0001-8215-9127
Emily N ReinkeU.S. Army Public Health Center, 8252 Blackhawk Rd., Aberdeen Proving Ground, MD 21010, USA.
Alexandre J S RibeiroU.S. Food and Drug Administration, Center for Drug Evaluation and Research, 10903 New Hampshire Avenue, Silver Spring, MD 20903, USA.
Nisha SipesU.S. Environmental Protection Agency, Center for Computational Toxicology and Exposure, 109 TW Alexander Dr., Research Triangle Park, NC 27711, USA.
Lisa M SweeneyUES, Inc., 4401 Dayton-Xenia Road, Beavercreek, OH 45432, Assigned to Air Force Research Laboratory, 711 Human Performance Wing, Wright-Patterson Air Force Base, OH 45433, USA.
John F WambaughU.S. Environmental Protection Agency, Center for Computational Toxicology and Exposure, 109 TW Alexander Dr., Research Triangle Park, NC 27711, USA.
Ronald WangeU.S. Food and Drug Administration, Center for Drug Evaluation and Research, 10903 New Hampshire Avenue, Silver Spring, MD 20903, USA.ORCID 0000-0001-9593-3572
Barbara A WetmoreU.S. Environmental Protection Agency, Center for Computational Toxicology and Exposure, 109 TW Alexander Dr., Research Triangle Park, NC 27711, USA.
Moiz MumtazAgency for Toxic Substances and Disease Registry, Office of the Associate Director for Science, 1600 Clifton Road, S102-2, Atlanta, GA 30333, USA.
Environmental Protection Agency · USUnited States Food and Drug Administration · USWright-Patterson Air Force Base · USAgency for Toxic Substances and Disease Registry · USCenter for Food Safety and Applied Nutrition · USHenry M. Jackson Foundation · USJoint Research Centre · ITNational Center for Biotechnology Information · USNational Center for Toxicological Research · USNational Institute of Environmental Health Sciences · USNational Institute of Standards and Technology · USUnited States Consumer Product Safety Commission · USU.S. Army Center for Health Promotion and Preventive Medicine · US
Funding
National Biomedical Information ServicesZIHLM200888 · NLM · NATIONAL LIBRARY OF MEDICINE · PI PALTOO, DINA · 2009 to 2025
$5200.7MScientific Cyberinfrastructure Research ProgramZIAES103385 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, VICKIE · 2022 to 2025
$17.4MNovel Tools and Approaches Research ProgramZIAES103378 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CRIZER, DAVID · 2022 to 2025
$11.2MResearch Operations Supporting the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological MethodsZICES103386 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI HOGBERG-DURDOCK, HELENA · 2022 to 2025
$3.3MNIEHS NIH HHS HHSN273201500010C
Abstract
During the past few decades, the science of toxicology has been undergoing a transformation from observational to predictive science. New approach methodologies (NAMs), including
Indexed as
absorptiondistributiondosimetryexcretion (ADME)Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM)in vitro to in vivo extrapolation (IVIVE)metabolismnew approach methodologies (NAMs)physiologically based pharmacokinetic (PBPK) modelrisk assessmenttoxicity tests
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.