Evidence map›Paper›PMID 35622437›Full record

ArticleCirculation. Arrhythmia and electrophysiology2022

Mapping Atrial Fibrillation After Surgical Therapy to Guide Endocardial Ablation.

Neal K Bhatia, Rajan L Shah, Brototo Deb, Terrence Pong, Ridhima Kapoor, Albert J Rogers, Nitish Badhwar, Chad Brodt, Paul J Wang, Sanjiv M Narayan and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. 2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Neal K Bhatia *Department of Cardiovascular Medicine (N.K.B., R.L.S., B.D., R.K., A.J.R., N.B., C.B., P.J.W., S.M.N.), Stanford University School of Medicine, CA.ORCID 0000-0002-8021-6631
Rajan L Shah *Department of Cardiovascular Medicine (N.K.B., R.L.S., B.D., R.K., A.J.R., N.B., C.B., P.J.W., S.M.N.), Stanford University School of Medicine, CA.ORCID 0000-0002-3603-7345
Brototo Deb *Department of Cardiovascular Medicine (N.K.B., R.L.S., B.D., R.K., A.J.R., N.B., C.B., P.J.W., S.M.N.), Stanford University School of Medicine, CA.ORCID 0000-0001-8800-0002
Terrence PongDepartment of Cardiothoracic Surgery (T.P., A.M.L.), Stanford University School of Medicine, CA.ORCID 0000-0003-4382-9890
Ridhima KapoorDepartment of Cardiovascular Medicine (N.K.B., R.L.S., B.D., R.K., A.J.R., N.B., C.B., P.J.W., S.M.N.), Stanford University School of Medicine, CA.ORCID 0000-0002-6097-7441
Albert J RogersDepartment of Cardiovascular Medicine (N.K.B., R.L.S., B.D., R.K., A.J.R., N.B., C.B., P.J.W., S.M.N.), Stanford University School of Medicine, CA.ORCID 0000-0001-6585-534X
Nitish BadhwarDepartment of Cardiovascular Medicine (N.K.B., R.L.S., B.D., R.K., A.J.R., N.B., C.B., P.J.W., S.M.N.), Stanford University School of Medicine, CA.ORCID 0000-0002-3233-6305
Chad BrodtDepartment of Cardiovascular Medicine (N.K.B., R.L.S., B.D., R.K., A.J.R., N.B., C.B., P.J.W., S.M.N.), Stanford University School of Medicine, CA.ORCID 0000-0002-2790-5040
Paul J WangDepartment of Cardiovascular Medicine (N.K.B., R.L.S., B.D., R.K., A.J.R., N.B., C.B., P.J.W., S.M.N.), Stanford University School of Medicine, CA.ORCID 0000-0002-5467-5877
Sanjiv M Narayan *Department of Cardiovascular Medicine (N.K.B., R.L.S., B.D., R.K., A.J.R., N.B., C.B., P.J.W., S.M.N.), Stanford University School of Medicine, CA.ORCID 0000-0001-7552-5053
Anson M Lee *Department of Cardiothoracic Surgery (T.P., A.M.L.), Stanford University School of Medicine, CA.
Stanford University · USCardiovascular Institute of the South · USEmory University · US

Funding

The Dynamics of Human Atrial FibrillationR01HL083359 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sanjiv M Narayan · 2008 to 2026
$7.9M
Machine Learning in Atrial FibrillationR01HL149134 · NHLBI · STANFORD UNIVERSITY · PI NARAYAN, SANJIV M · 2020 to 2024
$3.8M
Electrical Mapping Signatures of Adverse Structural and Functional Remodeling in Ventricular ArrhythmiaK23HL166977 · NHLBI · STANFORD UNIVERSITY · PI Albert Joseph Rogers · 2023 to 2026
$680k
NHLBI NIH HHS K23 HL166977NHLBI NIH HHS L30 HL143631NHLBI NIH HHS R01 HL083359NHLBI NIH HHS R01 HL149134
6 · The paper itself

Abstract

backgroundSurgical ablation for atrial fibrillation (AF) can be effective, yet has mixed results. It is unclear which endocardial lesions delivered as part of hybrid therapy' will best augment surgical lesion sets in individual patients. We addressed this question by systematically mapping AF endocardially after surgical ablation and relating findings to early recurrence, then performing tailored endocardial ablation as part of hybrid therapy.

methodsWe studied 81 consecutive patients undergoing epicardial surgical ablation (stage 1 hybrid), of whom 64 proceeded to endocardial catheter mapping and ablation (stage 2). Stage 2 comprised high-density mapping of pulmonary vein (PV) or posterior wall (PW) reconnections, low-voltage zones (LVZs), and potential localized AF drivers. We related findings to postsurgical recurrence of AF.

resultsMapping at stage 2 revealed PW isolation reconnection in 59.4%, PV isolation reconnection in 28.1%, and LVZ in 42.2% of patients. Postsurgical recurrence of AF occurred in 36 patients (56.3%), particularly those with long-standing persistent AF (

conclusionsAfter surgical ablation, AF may recur by several modes particularly related to localized mechanisms near low voltage zones, recovery of posterior wall or pulmonary vein isolation, or other sustaining mechanisms. LVZs are more common in patients at high clinical risk for recurrence. Patient-specific targeting of these mechanisms yields excellent long-term outcomes from hybrid ablation.

Indexed as

Atrial FibrillationCatheter AblationPulmonary VeinsElectrophysiologic Techniques, CardiacHumansRecurrenceTreatment Outcomeatrial fibrillationcathetershumanspulmonary veinssurgery

Identifiers

PMID35622437
PMCPMC9839337
OpenAlexW4281871153

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.