Evidence map›Paper›PMID 35622390›Full record

ArticleEnvironmental health perspectives2022

Drinking Water Disinfection Byproducts, Ingested Nitrate, and Risk of Endometrial Cancer in Postmenopausal Women.

Danielle N Medgyesi, Britton Trabert, Joshua Sampson, Peter J Weyer, Anna Prizment, Jared A Fisher, Laura E Beane Freeman, Mary H Ward, Rena R Jones

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
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  7. Article
  8. Disinfection byproducts in US drinking water and cancer mortality.International journal of environmental health research · 2025
    Article
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Danielle N MedgyesiOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA.ORCID 0000-0001-8825-5750
Britton TrabertMetabolic Epidemiology Branch, DCEG, NCI, NIH, DHHS, Bethesda, Maryland, USA.
Joshua SampsonBiostatistics Branch, DCEG, NCI, NIH, DHHS, Bethesda, Maryland, USA.
Peter J WeyerCenter for Health Effects of Environmental Contamination, University of Iowa, Iowa City, Iowa, USA.
Anna PrizmentDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
Jared A FisherOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA.
Laura E Beane FreemanOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA.
Mary H WardOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA.ORCID 0000-0001-7584-8856
Rena R JonesOccupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA.
National Institutes of Health · USUnited States Department of Health and Human Services · USUniversity of Iowa · USUniversity of Minnesota · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisinfection byproducts (DBPs) and

objectivesWe investigated the relationship of these exposures with endometrial cancer risk in a large prospective cohort.

methodsAmong postmenopausal women in the Iowa Women's Health Study cohort, we evaluated two major classes of DBPs, total trihalomethanes (TTHM) and five haloacetic acids (HAA5), and nitrate-nitrogen (

resultsHigher average concentrations of DBPs (95th percentile: TTHM DISCUSSION: We report novel associations between the highest DBP levels and endometrial cancer for our Iowa cohort that warrant future evaluation. https://doi.org/10.1289/EHP10207.

Indexed as

Drinking WaterEndometrial NeoplasmsDisinfectionFemaleHumansNitratesNitrogen OxidesPostmenopauseProspective StudiesRisk FactorsTrihalomethanesDrinking WaterNitratesNitrogen OxidesTrihalomethanes

Identifiers

PMID35622390
PMCPMC9138501
OpenAlexW4281699884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.