Evidence map›Paper›PMID 35622320›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Immunoglobulin/T-Cell Receptor Gene Rearrangement Analysis Using RNA-Seq.

Vincent H J van der Velden, Lorenz Bastian, Monika Brüggemann, Alina M Hartmann, Nikos Darzentas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vincent H J van der VeldenDepartment of Immunology, Laboratory Medical Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. v.h.j.vandervelden@erasmusmc.nl.
Lorenz BastianDepartment of Hematology, University of Schleswig-Holstein, Kiel, Germany.
Monika BrüggemannDepartment of Hematology, University of Schleswig-Holstein, Kiel, Germany.
Alina M HartmannDepartment of Hematology, University of Schleswig-Holstein, Kiel, Germany.
Nikos DarzentasDepartment of Hematology, University of Schleswig-Holstein, Kiel, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identification of immunoglobulin (IG) and T-cell receptor (TR) gene rearrangements in acute lymphoblastic leukemia (ALL) patients at initial presentation are crucial for monitoring of minimal residual disease (MRD) during subsequent follow-up and thereby for appropriate risk-group stratification. Here we describe how RNA-Seq data can be generated and subsequently analyzed with ARResT/Interrogate to identify possible MRD markers. In addition to the procedures, possible pitfalls will be discussed. Similar strategies can be employed for other lymphoid malignancies, such as lymphoma and myeloma.

Indexed as

Gene RearrangementGenes, T-Cell ReceptorImmunoglobulinsNeoplasm, ResidualPrecursor Cell Lymphoblastic Leukemia-LymphomaRNA-SeqAftercareHumansRisk AssessmentImmunoglobulinsAcute lymphoblastic leukemiaGene rearrangementsImmunoglobulinMarker identificationMinimal residual diseaseRNA-SeqT-cell receptorWhole exome sequencingWhole genome sequencing

Identifiers

PMID35622320
PMCPMC9761498

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.