Evidence map›Paper›PMID 35622296›Full record

ArticleHead and neck pathology2022

Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study.

Ibrahim Alsanie, Shahad Rajab, Hannah Cottom, Oluyori Adegun, Reshma Agarwal, Amrita Jay, Laura Graham, Jacqueline James, A William Barrett, Willie van Heerden and 18 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Head and neck pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 2 pooled it
24.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.

  1. Pooled it
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  4. The clinical outcomes and overall survival in patients with mucoepidermoid and adenoid cystic carcinoma of the salivary glands: A comparative analysis of long-term outcomes.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  6. Robotic-assisted parotidectomy as a remote-access alternative to conventional open surgery: a single-center comparative experience.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  12. Deep learning-based histopathological classification and subclassification of benign and malignant salivary gland tumors.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 16 institutions in 7 countries.

Ibrahim AlsanieUnit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, S10 2TA, UK.
Shahad RajabDental Hospital, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Hannah CottomBarts Health NHS Trust, London, UK.
Oluyori AdegunUniversity College London Hospitals NHS Foundation Trust, London, UK.
Reshma AgarwalUniversity College London Hospitals NHS Foundation Trust, London, UK.
Amrita JayUniversity College London Hospitals NHS Foundation Trust, London, UK.
Laura GrahamHealth Sciences Building, Regional Molecular Diagnostic Service, Belfast Health and Social Care Trust, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland.
Jacqueline JamesHealth Sciences Building, Regional Molecular Diagnostic Service, Belfast Health and Social Care Trust, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland.
A William BarrettDepartment of Histopathology, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, RH19 3DZ, UK.
Willie van HeerdenDepartment of Oral Pathology and Oral Biology, Faculty of Health Sciences, School of Dentistry, University of Pretoria, Pretoria, South Africa.
Mariano de VitoDepartment of Pathology -ULSS6 Euganea, Camposampiero, PD, Italy.
Alessandra CanessoDepartment of Pathology -ULSS6 Euganea, Camposampiero, PD, Italy.
Akinyele Olumuyiwa AdisaUniversity of Ibadan and University College Hospital Ibadan, Ibadan, Nigeria.
Abdul-Warith Olaitan AkinshipoUniversity of Lagos, Lagos, Nigeria.
Oluseyi Folake AjayiUniversity of Lagos, Lagos, Nigeria.
Mark Chukwuemeka NwogaUniversity of Nigeria Teaching Hospital, Enugu, Nigeria.
Chukwubuzor Udokwu OkwuosaUniversity of Nigeria Teaching Hospital, Enugu, Nigeria.
Olufemi Gbenga OmitolaUniversity of Port-Harcourt and University of Port-Harcourt Teaching Hospital, Port Harcourt, Nigeria.
Efetobo Victor OrikpeteUniversity of Port-Harcourt and University of Port-Harcourt Teaching Hospital, Port Harcourt, Nigeria.
Merva Soluk-TekkesinDepartment of Tumour Pathology, Institute of Oncology, Istanbul University, Istanbul, Turkey.
Ibrahim O BelloDepartment of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Ahmed QannamDepartment of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Wilfredo GonzalezFacultad de Odontología, Universidad de Valparaíso, Valparaiso, Chile.
Maria Eduarda Pérez-de-OliveiraOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
Alan Roger Santos-SilvaOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
Pablo Agustin VargasDepartment of Oral Pathology and Oral Biology, Faculty of Health Sciences, School of Dentistry, University of Pretoria, Pretoria, South Africa.
Eu-Wing TohDepartment of Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, S10 2JF, UK.
Syed Ali KhurramUnit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, S10 2TA, UK. s.a.khurram@sheffield.ac.uk.ORCID http://orcid.org/0000-0002-0378-9380
King Saud University · SAUniversidade Estadual de Campinas (UNICAMP) · BRUniversity College London Hospitals NHS Foundation Trust · GBUniversity of Lagos · NGUniversity of Nigeria Teaching Hospital · NGUniversity of Port Harcourt Teaching Hospital · NGBarts Health NHS Trust · GBIstanbul University · TRKing Abdulaziz University · SAQueen's University Belfast · GBQueen Victoria Hospital · GBSheffield Teaching Hospitals NHS Foundation Trust · GBUniversidad de Los Andes, Chile · CLUniversity of Ibadan · NGUniversity of Pretoria · ZAUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSalivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only.

methodsThis study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. The analysed data included age, gender, location and histological diagnosis from fifteen centres covering the majority of the world health organisation (WHO) geographical regions between 2006 and 2019.

resultsA total of 5739 cases were analysed including 65% benign and 35% malignant tumours. A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed. The majority (68%) of the SGT presented in major and 32% in the minor glands. The parotid gland was the most common location (70%) for benign and minor glands (47%) for malignant tumours. Pleomorphic adenoma (70%), and Warthin's tumour (17%), were the most common benign tumours whereas mucoepidermoid carcinoma (26%) and adenoid cystic carcinoma (17%) were the most frequent malignant tumours.

conclusionsThis multicentre investigation presents the largest cohort study to date analysing salivary gland tumour data from tertiary centres scattered across the globe. These findings should serve as a baseline for future studies evaluating the epidemiological landscape of these tumours.

Indexed as

Salivary Gland NeoplasmsCohort StudiesFemaleHumansDemographicsEpidemiologyHead and neckHistological diagnosisMulticentre research studySalivary gland neoplasmsSalivary gland tumoursSite distribution

Identifiers

PMID35622296
PMCPMC9729635
OpenAlexW4281626864

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.