Evidence map›Paper›PMID 35622253›Full record

ArticleBulletin of experimental biology and medicine2022

Synergy between the Levels of Methylation of microRNA Gene Sets in Primary Tumors and Metastases of Ovarian Cancer Patients.

S S Lukina, A M Burdennyy, E A Filippova, I V Pronina, N A Ivanova, T P Kazubskaya, D N Kushlinskii, D O Utkin, V I Loginov, E A Braga and 1 more

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

S S LukinaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
A M BurdennyyResearch Institute of General Pathology and Pathophysiology, Moscow, Russia. burdennyy@gmail.com.
E A FilippovaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
I V ProninaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
N A IvanovaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
T P KazubskayaN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
D N KushlinskiiN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
D O UtkinN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
V I LoginovResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
E A BragaResearch Institute of General Pathology and Pathophysiology, Moscow, Russia.
N E KushlinskiiN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RUMinistry of Health of the Russian Federation · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the correlations between the levels of methylation of a group of 21 microRNA genes in 99 primary tumors and 29 macroscopic peritoneal metastases of ovarian cancer. Analysis of the level of methylation by quantitative methylation-specific PCR showed that co-methylation was detected for 13 pairs of microRNA genes in primary tumors and for 22 pairs in metastases. Pairs of microRNA genes that have shown significant co-methylation can be involved in common processes and pathways of gene regulation and interaction and can have common target genes. The results are highly significant and pairs of microRNA genes can be proposed as new potential markers for the diagnosis and prognosis of ovarian cancer metastasis.

Indexed as

MicroRNAsOvarian NeoplasmsCarcinoma, Ovarian EpithelialDNA MethylationFemaleGene Expression Regulation, NeoplasticHumansMicroRNAsmicroRNA genesovarian cancerperitoneal metastasesprimary tumorssynergism

Identifiers

PMID35622253
OpenAlexW4281623021

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.