SynthesisPrevention science : the official journal of the Society for Prevention Research2023
Is Stress an Overlooked Risk Factor for Dementia? A Systematic Review from a Lifespan Developmental Perspective.
Synthesis in Prevention science : the official journal of the Society for Prevention Research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationship Between Clusters of Multimorbidity and Dementia Risk: A Systematic Review.International journal of geriatric psychiatry · 2025Pooled it
- A digitally supported multimodal lifestyle program to promote brain health among older adults (the LETHE randomized controlled feasibility trial): study design, progress, and first results.Alzheimer's research & therapy · 2024Trial
- Oxytocin as regulator of stress and inflammation in aging.Neuroscience and biobehavioral reviews · 2026Review
- The long-term impact of adverse childhood experiences on episodic memory in mid- to late-life among US older adults.Aging & mental health · 2026Article
- Longevity.Clinical medicine & research · 2026Review
- The association between adverse experiences throughout the life-course and risk of dementia in the English Longitudinal Study of Ageing.Journal of Alzheimer's disease : JAD · 2026Article
- Review
- Cognitive Aging in the Context of the Housing Crisis: Trends and Evidence From the Health and Retirement Study.Canadian studies in population · 2026Article
- Association Between Structural and Social Determinants of Health and Cognitive Functioning Among African Americans: the ARCHES Cohort.Journal of racial and ethnic health disparities · 2025Article
- Association between autism and dementia across generations: evidence from a family study of the Swedish population.Molecular psychiatry · 2025Article
- Age at First Childbirth and Dementia Risk: A Cross-Sectional Ecological Analysis of Female Prevalence, Sex Disparities, and Public Health Implications.Health science reports · 2025Article
- Early Onset Memory Deficit of WMI Rats Compared to Their Nearly Isogenic WLIs Is Reversed by Enriched Environment in Females.Genes, brain, and behavior · 2025Article
- The Intersecting Effects of Lifetime Experiences of Homelessness and Incarceration on Cognitive Aging and Dementia Risk Factors in the United States.The Gerontologist · 2025Article
- Circulating Stress Hormones, Brain Health, and Cognition in Healthy Older Adults: Cross-Sectional Findings and Sex Differences in Age-Well.Biological psychiatry global open science · 2025Article
- Life course exposure to work strain and cognitive disparities by race and ethnicity.SSM - population health · 2025Article
- Article
- Screening mild cognitive impairment using aspects of personal, social, and functional lifestyle: Machine Learning Approaches.PloS one · 2025Article
- Group music therapy for the proactive management of stress and anxiety.PLOS mental health · 2025Article
- Article
- Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations.The lancet. Healthy longevity · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Stress exposure and stress reactivity may be potent factors associated with increased risk of dementia. The 2017 Lancet Commission on Dementia and its 2020 update reviewed modifiable risk factors associated with dementia, but stress was not addressed directly. The present study provides a focused review of the association between stress and dementia across the lifespan, with measures of stress including stress exposure, psychological stress, posttraumatic stress disorder (PTSD), and biological markers of stress. Published research articles were identified in the American Psychological Association PsycINFO database (1887-2021), Web of Science database, and Google Scholar. A total of 53 samples from 40 studies published from 1985 to 2020 met inclusion criteria. Results suggest that stressful life events that occur earlier in the lifespan, such as loss of a parent, psychological stress experienced in midlife, and extreme stress responses, i.e., PTSD, correlate with higher risk of dementia. Although results generally are mixed, a consistent theme is that stress experienced earlier in the lifespan and chronic stress portend the greatest risk of dementia. Reducing stress exposure and improving stress management when stress exposure cannot be changed are thus relevant strategies in dementia risk reduction.
Indexed as
Identifiers
35622193What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.