Evidence map›Paper›PMID 35622145›Full record

ArticleVirchows Archiv : an international journal of pathology2022

CD2-negative lymphoma-associated T-cells: a potential mechanism of immune-evasion in diffuse large B-cell lymphoma.

Anindita Ghosh, Mario L Marques-Piubelli, Xiaoqiong Wang, Tiffany G Sheu, Joanne Cheng, Khaja Khan, Wei Lu, John Manning, Guilin Tang, Luisa M Solis and 1 more

Abstract readCase Reports
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Anindita Ghosh *Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center, Houston, TX, USA.
Mario L Marques-Piubelli *Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xiaoqiong WangDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Tiffany G SheuDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
Joanne ChengDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Khaja KhanDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wei LuDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
John ManningDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Guilin TangDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Luisa M SolisDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Francisco VegaDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. fvega@mdanderson.org.ORCID http://orcid.org/0000-0001-5956-452X
The University of Texas MD Anderson Cancer Center · USMethodist Hospital · USThe University of Texas Health Science Center at Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD2 is a costimulatory protein expressed in all mature T/NK-cells, in particular memory T-cells. CD58 (or LFA-3) is the receptor for CD2 and is ubiquitously expressed. CD2-CD58 interaction has key functions in T-cell activation and organization of the immunological synapse between T- and antigen-presenting cells. Cancer cells have developed multiple mechanisms to evade immune surveillance. Loss of CD58 expression is one frequently reported in diffuse large B-cell lymphomas (DLBCL). On the other hand, in non-hematological neoplasms, tumor infiltrating lymphocytes (TILs) with reduced expression of CD2 have been associated with defective cytotoxicity and T-cell exhaustion. Here, we reported a case of DLBCL involving the jejunal mucosa associated with a rim of cytotoxic reactive T-cells with features of immune evasion (CD2- and TCR-) and T-cell exhaustion (PD1 + high). This case likely exemplifies a previously unrecognized immune evasion mechanism in lymphoma involving a decreased CD2 expression in the lymphoma-associated T-cells.

Indexed as

Lymphoma, Large B-Cell, DiffuseLymphoma, T-CellCD2 AntigensCD58 AntigensHumansImmune EvasionLymphocyte ActivationReceptors, Antigen, T-CellCD2 AntigensCD58 AntigensReceptors, Antigen, T-CellCD2CD58Diffuse large B-cell lymphomaImmune evasionLymphoma-associated lymphoid cells

Identifiers

PMID35622145
OpenAlexW4281889616

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.