Evidence map›Paper›PMID 35622143›Full record

ArticleCellular and molecular life sciences : CMLS2022

PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As

Xinping Huang, Yongfeng Yang, Dan Zhu, Yan Zhao, Min Wei, Ke Li, Hong-Hu Zhu, Xiaofeng Zheng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xinping Huang *State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, 100871, China.
Yongfeng Yang *State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, 100871, China.
Dan ZhuState Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, 100871, China.
Yan ZhaoState Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, 100871, China.
Min WeiState Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, 100871, China.
Ke LiNHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hong-Hu ZhuDepartment of Hematology and Institute of Hematology, Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Xiaofeng ZhengState Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, 100871, China. xiaofengz@pku.edu.cn.ORCID http://orcid.org/0000-0001-6790-0669
Peking University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNFirst Affiliated Hospital Zhejiang University · CN

Funding

National Natural Science Foundation of China 81730080National Natural Science Foundation of China 82130081Natural Science Foundation of Beijing Municipality 5212008
6 · The paper itself

Abstract

Acute promyelocytic leukemia (APL) is a hematological malignancy driven by the oncoprotein PML-RARα, which can be treated with arsenic trioxide (As

Indexed as

Drug Resistance, NeoplasmLeukemia, Promyelocytic, AcuteAnimalsAntineoplastic AgentsArsenic TrioxideCell Line, TumorHumansIsoquinolinesMethylationMiceNuclear ProteinsOncogene Proteins, FusionProtein-Arginine N-MethyltransferasesPyrimidinesTranscription FactorsUbiquitinationAntineoplastic AgentsArsenic TrioxideGSK3235025IsoquinolinesNuclear ProteinsOncogene Proteins, FusionPRMT5 protein, humanpromyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinProtein-Arginine N-MethyltransferasesPyrimidinesRNF4 protein, humanTranscription FactorsAcute promyelocytic leukemiaMethylationPML-RARαPRMT5RNF4Ubiquitination

Identifiers

PMID35622143
PMCPMC11072021
OpenAlexW4281619360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.