Evidence map›Paper›PMID 35622118›Full record

ArticleCancer immunology, immunotherapy : CII2022

Functional expression of CD73 on human natural killer cells.

Andrea M Chambers, Jiao Wang, Tram N Dao, Kyle B Lupo, Paige Veenhuis, Mitchell G Ayers, Veronika Slivova, Aaron A Cohen-Gadol, Sandro Matosevic

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Andrea M ChambersDepartment of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, 47907, USA.
Jiao WangDepartment of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, 47907, USA.
Tram N DaoDepartment of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, 47907, USA.
Kyle B LupoDepartment of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, 47907, USA.
Paige VeenhuisDepartment of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, 47907, USA.
Mitchell G AyersDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, 47907, USA.
Veronika SlivovaEnterprise Clinical Research Operations Biorepository, Indiana University Health, Indianapolis, IN, 46202, USA.
Aaron A Cohen-GadolDepartment of Neurological Surgery, Indiana University, Indianapolis, IN, USA.
Sandro MatosevicDepartment of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN, 47907, USA. sandro@purdue.edu.ORCID http://orcid.org/0000-0001-5118-2455
Purdue University West Lafayette · USIndiana University Health · USNeurological Surgery · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The production of adenosine by CD73 on cancer cells in the tumor microenvironment is a recognized immunosuppressive mechanism contributing to immune evasion in many solid tumors. While NK cells have been purported to overexpress CD73 under certain conditions, this phenomenon has remained elusive and unclear. We have found that while NK cells are able to upregulate expression of CD73 on their surface when exposed to CD73

Indexed as

GlioblastomaKiller Cells, Natural5'-NucleotidaseAdenosineGPI-Linked ProteinsHepatitis A Virus Cellular Receptor 2HumansTumor Microenvironment5'-NucleotidaseAdenosineGPI-Linked ProteinsHepatitis A Virus Cellular Receptor 2NT5E protein, humanAdenosineCD73ImmunometabolismNK cellsTumor microenvironment

Identifiers

PMID35622118
PMCPMC10992443
OpenAlexW4281608627

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.