ArticleMarine drugs2022
The Impact of Natural Deep Eutectic Solvents and Extraction Method on the Co-Extraction of Trace Metals from
Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- From Oilseed Waste to High-Value Bioactives: Deep Eutectic Solvents as Sustainable Refining Media.International journal of molecular sciences · 2026Review
- Review
- Recent Advances in NADES-Assisted Process Intensification Technologies for Sustainable Recovery of Microalgal Bioactives: Challenges and Future Prospectives.Marine drugs · 2026Review
- Multifunctional NADES-Based Extracts fromMolecules (Basel, Switzerland) · 2025Article
- Extraction and Identification of Active Components fromMolecules (Basel, Switzerland) · 2025Article
- NaDES-Based Extracts by Microwave Activation fromMolecules (Basel, Switzerland) · 2025Article
- Sustainable Extraction of Prospective Cosmetic Ingredients from Colombian Marine Macroalgae Using Natural Deep Eutectic Solvents.Marine drugs · 2025Article
- Deep Eutectic Systems: A Game Changer for Marine Bioactives Recovery.Marine drugs · 2025Review
- Exploring Phenolic Compounds Extraction from Saffron (Molecules (Basel, Switzerland) · 2024Article
- From Nature to Innovation: The Uncharted Potential of Natural Deep Eutectic Solvents.Molecules (Basel, Switzerland) · 2023Review
- Arctic Edible Brown AlgaPlants (Basel, Switzerland) · 2023Article
- Optimization of Extraction of Phlorotannins from the ArcticMarine drugs · 2023Article
- The Ability of Acid-Based Natural Deep Eutectic Solvents to Co-Extract Elements from the Roots ofMolecules (Basel, Switzerland) · 2022Article
- A Critical Comparison of the Advanced Extraction Techniques Applied to Obtain Health-Promoting Compounds from Seaweeds.Marine drugs · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
In recent years, natural deep eutectic solvents (NADES) have been widely investigated for the extraction of food and medicinal plants as well as seaweeds. However, the ability of NADES for trace elements co-extraction from natural sources is not well investigated. The aim of this study was to investigate the ability of common NADES for trace elements co-extraction from Fucus vesiculosus. All of the tested NADES did not recover As and Co (concentration <LOQ). Moreover, all of the tested NADES provided a low recovery (<9%) of Ba, Ca, Fe, Mg, Mn, Sr, and Zn. The method of extraction had not shown a statistically significant effect on the co-extraction of all elements (excluding Ba and Ca). In contrast, the water content in NADES was significantly affected on the recovery of Ba, Ca, Mg, Mn, Sr, and Zn. The recovery of Al and Cr was relatively high and considerably varied (from 1.5 to 59.9%). NADES comprising lactic acid:glucose:H2O (5:3:1) provided the lowest contents of all elements, and the highest extracted amounts were obtained employing water contents of 60−80%. The calculated daily intake of all the elements contained in NADES extracts were less than the daily dose risk estimators. The hazard quotients, hazard indexes, and carcinogenic risk calculated for all trace elements and their combination were considerably less than 1. This evidences no health risk, and carcinogenic risk after topical application of all studied NADES. For the first time, the results of the current study demonstrated that NADES extracts of F. vesiculosus contain a lower amount of trace metals and are safer than the extracts obtained with water and 70% acetone. This indicates a significant advantage for NADES compared with the other solvents.
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Registered trials
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