Evidence map›Paper›PMID 35621690›Full record

ReviewCurrent oncology (Toronto, Ont.)2022

HRAS Q61L Mutation as a Possible Target for Non-Small Cell Lung Cancer: Case Series and Review of Literature.

Laurent Mathiot, Guillaume Herbreteau, Siméon Robin, Charlotte Fenat, Jaafar Bennouna, Christophe Blanquart, Marc Denis, Elvire Pons-Tostivint

Open access · goldAbstract readCase ReportsReview
In one paragraph

Review in Current oncology (Toronto, Ont.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Laurent MathiotService d'Oncologie Médicale, CHU Nantes, Nantes Université, F-44000 Nantes, France.
Guillaume HerbreteauUMR 1302/EMR6001, INCIT, Immunology and New Concepts in ImmunoTherapy, CNRS, INSERM, Laboratoire de Biochimie, CHU Nantes, Nantes Université, F-44000 Nantes, France.ORCID 0000-0003-3705-2114
Siméon RobinPharmacie, CHU Nantes, Nantes Université, F-44000 Nantes, France.
Charlotte FenatPharmacie, CHU Nantes, Nantes Université, F-44000 Nantes, France.
Jaafar BennounaDepartment of Medical Oncology, Hospital Foch, F-92073 Suresnes, France.
Christophe BlanquartNantes Université, Inserm UMR 1307, CNRS UMR 6075, Université d'Angers, CRCI2NA, F-44000 Nantes, France.ORCID 0000-0002-0917-3747
Marc DenisUMR 1302/EMR6001, INCIT, Immunology and New Concepts in ImmunoTherapy, CNRS, INSERM, Laboratoire de Biochimie, CHU Nantes, Nantes Université, F-44000 Nantes, France.ORCID 0000-0001-5865-3248
Elvire Pons-TostivintService d'Oncologie Médicale, CHU Nantes, Nantes Université, F-44000 Nantes, France.ORCID 0000-0003-4478-0523
Centre National de la Recherche Scientifique · FRNantes Université · FRHôpital Foch · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAssessment of actionable gene mutations and oncogene fusions have made a paradigm shift in treatment strategies of non-small cell lung cancer (NSCLC).

methodsNext-Generation Sequencing (NGS) done routinely at Nantes University Hospital was used to identify

resultsOf 1614 patients diagnosed with advanced NSCLC from January 2018 to December 2020, four (0.25%) had

conclusionsThe clinical course of patients with

Indexed as

Antineoplastic AgentsCarcinoma, Non-Small-Cell LungLung NeoplasmsHumansMutationProto-Oncogene Proteins p21(ras)Antineoplastic AgentsHRAS protein, humanProto-Oncogene Proteins p21(ras)HRAS Gln61Leunon-small cell lung canceroncogenic drivertipifarnib

Identifiers

PMID35621690
PMCPMC9139372
OpenAlexW4280522194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.