ArticleGels (Basel, Switzerland)2022
Eco-Friendly Synthesized PVA/Chitosan/Oxalic Acid Nanocomposite Hydrogels Embedding Silver Nanoparticles as Antibacterial Materials.
Article in Gels (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Combined Effect: Development and Physical/Biological Assessment of PVA/Chitosan Hydrogels Containing rhTGF-β1-Loaded PLGA Nanoparticles.Gels (Basel, Switzerland) · 2026Article
- Scalable electrochemical COScientific reports · 2026Article
- In Situ Formation of Silver Nanoparticles-Containing Gallic Acid-Conjugated Chitosan Hydrogels as Antimicrobial Tissue Adhesive Materials.Biomimetics (Basel, Switzerland) · 2025Article
- Deposition of Ag/TMC Nanoparticles via MAPLE to Enhance the Mechanical and Antimicrobial Properties of Silicone Hydrogel.ACS omega · 2025Article
- One-Pot Synthesis of Gelatin/Gum Arabic Hydrogels Embedding Silver Nanoparticles as Antibacterial Materials.Gels (Basel, Switzerland) · 2025Article
- Therapies and delivery systems for diabetic wound care: current insights and future directions.Frontiers in pharmacology · 2025Review
- In Vitro and Randomized Controlled Clinical Study of Natural Constituents' Anti-HPV Potential for Treatment of Plantar Warts Supported with In Silico Studies and Network Analysis.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Bioactive injectable mucoadhesive thermosensitive natural polymeric hydrogels for oral bone and periodontal regeneration.Frontiers in bioengineering and biotechnology · 2024Review
- Formulation and Comprehensive Evaluation of Biohybrid Hydrogel Membranes Containing Doxycycline or Silver Nanoparticles.Pharmaceutics · 2023Article
- Tri-Component Hydrogel as Template for Nanocrystalline Hydroxyapatite Deposition Using Alternate Soaking Method for Bone Tissue Engineering Applications.Gels (Basel, Switzerland) · 2023Article
- Composite Hydrogels with Embedded Silver Nanoparticles and Ibuprofen as Wound Dressing.Gels (Basel, Switzerland) · 2023Article
- pH-Sensitive Degradable Oxalic Acid Crosslinked Hyperbranched Polyglycerol Hydrogel for Controlled Drug Release.Polymers · 2023Article
- PVA/Chitosan Thin Films Containing Silver Nanoparticles and Ibuprofen for the Treatment of Periodontal Disease.Polymers · 2022Article
- Silver Nanoparticles Biocomposite Films with Antimicrobial Activity: In Vitro and In Vivo Tests.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
PVA/chitosan (PVA/CS) composite hydrogels incorporating silver nanoparticles (AgNPs) were prepared by double-cross-linked procedures: freeze−thawing and electrostatic interactions. Oxalic acid (OA) was used both for solubilization and ionic cross-linking of CS. AgNPs covered by CS (CS-AgNPs) with an average diameter of 9 nm and 18% silver were obtained in the presence of CS, acting as reducing agent and particle stabilizer. The increase of the number of freeze−thaw cycles, as well as of the PVA:CS and OA:CS ratios, resulted in an increase of the gel fraction and elastic modulus. Practically, the elastic modulus of the hydrogels increased from 3.5 kPa in the absence of OA to 11.6 kPa at a 1:1 OA:CS weight ratio, proving that OA was involved in physical cross-linking. The physicochemical properties were not altered by the addition of CS-AgNPs in low concentration; however, concentrations higher than 3% resulted in low gel fraction and elastic modulus. The amount of silver released from the composite hydrogels is very low (<0.4%), showing that AgNPs were well trapped within the polymeric matrix. The composite hydrogels displayed antimicrobial activity against S. aureus, K. pneumoniae or P. gingivalis. The low cytotoxicity and the antibacterial efficacy of hydrogels recommend them for wound and periodontitis treatment.
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