Evidence map›Paper›PMID 35621474›Full record

ArticleBioengineering (Basel, Switzerland)2022

Automated Analysis of Acetaminophen Toxicity on 3D HepaRG Cell Culture in Microbioreactor.

Martin Baca, Dana Brauer, Maren Klett, Uta Fernekorn, Sukhdeep Singh, Jörg Hampl, G Alexander Groß, Patrick Mai, Karin Friedel, Andreas Schober

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. A Microfibrous Extracellular Matrix Platform forACS pharmacology & translational science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Martin BacaDepartment of Nano-Biosystems Engineering, Institute of Chemistry and Biotechnology, University of Technology, P.O. Box 10 05 65, 98684 Ilmenau, Germany.
Dana BrauerDepartment of Nano-Biosystems Engineering, Institute of Chemistry and Biotechnology, University of Technology, P.O. Box 10 05 65, 98684 Ilmenau, Germany.
Maren KlettDepartment of Nano-Biosystems Engineering, Institute of Chemistry and Biotechnology, University of Technology, P.O. Box 10 05 65, 98684 Ilmenau, Germany.
Uta FernekornDepartment of Nano-Biosystems Engineering, Institute of Chemistry and Biotechnology, University of Technology, P.O. Box 10 05 65, 98684 Ilmenau, Germany.
Sukhdeep SinghDepartment of Nano-Biosystems Engineering, Institute of Chemistry and Biotechnology, University of Technology, P.O. Box 10 05 65, 98684 Ilmenau, Germany.ORCID 0000-0001-6871-4294
Jörg HamplDepartment of Nano-Biosystems Engineering, Institute of Chemistry and Biotechnology, University of Technology, P.O. Box 10 05 65, 98684 Ilmenau, Germany.
G Alexander GroßDepartment of Nano-Biosystems Engineering, Institute of Chemistry and Biotechnology, University of Technology, P.O. Box 10 05 65, 98684 Ilmenau, Germany.ORCID 0000-0002-3996-5446
Patrick MaiDepartment of Nano-Biosystems Engineering, Institute of Chemistry and Biotechnology, University of Technology, P.O. Box 10 05 65, 98684 Ilmenau, Germany.
Karin FriedelDepartment of Nano-Biosystems Engineering, Institute of Chemistry and Biotechnology, University of Technology, P.O. Box 10 05 65, 98684 Ilmenau, Germany.
Andreas SchoberDepartment of Nano-Biosystems Engineering, Institute of Chemistry and Biotechnology, University of Technology, P.O. Box 10 05 65, 98684 Ilmenau, Germany.
Technische Universität Ilmenau · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Real-time monitoring of bioanalytes in organotypic cell cultivation devices is a major research challenge in establishing stand-alone diagnostic systems. Presently, no general technical facility is available that offers a plug-in system for bioanalytics in diversely available organotypic culture models. Therefore, each analytical device has to be tuned according to the microfluidic and interface environment of the 3D in vitro system. Herein, we report the design and function of a 3D automated culture and analysis device (3D-ACAD) which actively perfuses a custom-made 3D microbioreactor, samples the culture medium and simultaneously performs capillary-based flow ELISA. A microstructured MatriGrid

Indexed as

3D hepatocyte cultureacetaminophen toxicityalbuminflow-through ELISAHepaRGscaffold

Identifiers

PMID35621474
PMCPMC9137798
OpenAlexW4225271742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.