ArticleMedical physics2022
Preclinical dosimetry in proton minibeam radiation therapy: Robustness analysis and guidelines.
Article in Medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Impact of collimator misalignments on dosimetric robustness in proton minibeam radiotherapy using an automated measurement setup.Medical physics · 2026Article
- Roadmap for the implementation of particle minibeam therapy.Medical physics · 2026Review
- Collimator position optimization for proton minibeam radiation therapy.Scientific reports · 2026Article
- Collimator position optimization for proton minibeam radiation therapy.Research square · 2026Article
- Evaluation of Proton Minibeam Radiotherapy on Antitumor Immune Responses in a Rat Model of Glioblastoma.Cancer immunology research · 2025Article
- Collimated and non-collimated proton minibeam irradiation using SIRMIO: a simulation study.Acta oncologica (Stockholm, Sweden) · 2025Article
- Mini-GRID therapy delivers optimised spatially fractionated radiation therapy using a flattening free filter accelerator.Communications medicine · 2025Article
- Monte Carlo modeling of a commercial machine and experimental setup for FLASH-minibeam irradiations with electrons.Medical physics · 2025Article
- Are we overestimating proton minibeam therapy effectiveness through physical dose metrics?Frontiers in oncology · 2025Article
- Proton minibeam radiotherapy: a review.Frontiers in oncology · 2025Review
- Challenges for the Implementation of Primary Standard Dosimetry in Proton Minibeam Radiation Therapy.Cancers · 2024Article
- Review
- Comprehensive dosimetric commissioning of proton minibeam radiotherapy on a single gantry proton system.Frontiers in oncology · 2024Article
- Design and dosimetric characterization of a transportable proton minibeam collimation system.Frontiers in oncology · 2024Article
- Monocrystalline diamond detector for online monitoring during synchrotron microbeam radiotherapy.Journal of synchrotron radiation · 2023Article
- Preclinical dosimetry in proton minibeam radiation therapy: Robustness analysis and guidelines.Medical physics · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purposeProton minibeam radiation therapy (pMBRT) is a new radiotherapy approach that has shown a significant increase in the therapeutic window in glioma-bearing rats compared to conventional proton therapy. The dosimetry of pMBRT is challenging and error prone due to the submillimetric beamlet sizes used. The aim of this study was to perform a robustness analysis on the setup parameters utilized in current preclinical trials and provide guidelines for reproducible dosimetry. The results of this work are intended to guide upcoming implementations of pMBRT worldwide, as well as pave the way for future clinical implementations.
methodsMonte Carlo simulations and experimental data were used to evaluate the impact of variations in setup parameters and uncertainties in collimator specifications on lateral pMBRT dose distributions. The value of each parameter was modified individually to evaluate their effect on dose distributions. Experimental dosimetry was performed by means of high-resolution detectors, that is, radiochromic films, the IBA Razor and the Microdiamond detector. New guidelines were proposed to optimize the experimental setup in pMBRT studies and perform reproducible dosimetry.
resultsThe sensitivity of dose distributions to uncertainties and variations in setup parameters was quantified. Quantities that define pMBRT lateral profiles (i.e., the peak-to-valley dose ratio [PVDR], peak and valley doses, and peak width) are significantly influenced by small-scale fluctuations in several of those parameters. The setup implemented at the Orsay proton therapy center for pMBRT irradiation was optimized to increase PVDRs and peak symmetry. In addition, we proposed guidelines to perform accurate and reproducible dosimetry in preclinical studies.
conclusionsThis study revealed the importance of adopting guidelines and protocols tailored to the distinct dose delivery method and dose distributions in pMBRT. This new methodology leads to reproducible dosimetry, which is imperative in preclinical trials. The results and guidelines presented in this manuscript can ease the initiation of pMBRT investigations in other centers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.