Evidence map›Paper›PMID 35621246›Full record

ArticleClinical and translational science2022

First-in-human development of a pharmacodynamic biomarker for PAC

Heleen Marynissen, Linde Buntinx, Dorien Bamps, Marleen Depre, Els Ampe, Anne Van Hecken, Kristin Gabriel, Steve Sands, Gabriel Vargas, Jan de Hoon

Open access · goldAbstract readClinical Study
In one paragraph

Article in Clinical and translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. The biotechnological potential of proteases from hematophagous arthropod vectors.Frontiers in cellular and infection microbiology · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Heleen MarynissenCenter for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.ORCID 0000-0002-0041-1614
Linde BuntinxAnima Research Center, Alken, Belgium.
Dorien BampsCenter for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.ORCID 0000-0002-3441-4290
Marleen DepreCenter for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
Els AmpeCenter for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
Anne Van HeckenCenter for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
Kristin GabrielSpark Therapeutics, Member of the Roche Group, Philadelphia, Pennsylvania, USA.
Steve SandsAmgen Inc., Thousand Oaks, California, USA.
Gabriel VargasCuraSen Therapeutics, San Carlos, California, USA.
Jan de HoonCenter for Clinical Pharmacology, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.
KU Leuven · BEAmgen (United States) · USKaken Pharmaceutical (Japan) · JPRoche (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maxadilan, a potent vasodilator peptide, selectively activates the PAC

Indexed as

ForearmVasodilator AgentsBiomarkersHumansInjections, IntradermalReproducibility of ResultsBiomarkersVasodilator Agents

Identifiers

PMID35621246
PMCPMC9372410
OpenAlexW4281969357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.