ArticleJournal of the American Heart Association2022
Association of Vascular Properties With the Brain White Matter Hyperintensity in Middle-Aged Population.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2023Pooled it
- Threshold Effects, Cognitive Decline, and Longitudinal Changes in White Matter Hyperintensity Volume.Stroke · 2026Article
- The association between total SVD score and cardio-ankle vascular index.Neuroradiology · 2026Article
- The Role of the Cellular Communication Network Protein Family in Pulmonary Arterial Hypertension.Pulmonary circulation · 2026Article
- Association of Metabolic Dysfunction-Associated Steatotic Liver Disease With Features of Cerebral Small-Vessel Disease on Magnetic Resonance Images: A Large Cross-Sectional Study.Journal of the American Heart Association · 2026Article
- Deep medullary veins score is associated with idiopathic normal pressure hydrocephalus in patients with arteriolosclerotic cerebral small vessel disease.Frontiers in neuroscience · 2026Article
- Threshold Effects, Cognitive Decline, and Longitudinal Changes in White Matter Hyperintensity Volume.medRxiv : the preprint server for health sciences · 2025Article
- Racial and ethnic differences in cardiometabolic predictors of white matter hyperintensities burden among males: The HABS-HD study.Journal of Alzheimer's disease : JAD · 2025Article
- Deep Learning Analysis of White Matter Hyperintensity and its Association with Comprehensive Vascular Factors in Two Large General Populations.Journal of imaging informatics in medicine · 2025Article
- Differential impact of cerebral small vessel disease on thalamic regulation of anxiety: insights from 7T MRI.Molecular psychiatry · 2025Article
- APOE ε2 is associated with reduced risk of early post-stroke cognitive impairment but not with long-term functional outcome.BMC neurology · 2025Article
- Cellular Communication Network Protein 2 in the Right Ventricle of Pulmonary Arterial Hypertension.Pulmonary circulation · 2025Article
- Napkin-ring sign plaques are associated with cerebral small vessel disease.European journal of medical research · 2025Article
- Effects of Carotid plaque Crouse score and serum Hcy on the location of white matter hyperintensities.Frontiers in neurology · 2025Article
- Association of the Brain White Matter Hyperintensity with the Cognitive Performance in Middle-Aged Population.Cerebrovascular diseases (Basel, Switzerland) · 2025Article
- Cerebral Small Vessel Disease: a Review of the Pathophysiological Mechanisms.Translational stroke research · 2024Review
- Leukoaraiosis: Epidemiology, Imaging, Risk Factors, and Management of Age-Related Cerebral White Matter Hyperintensities.Journal of stroke · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Background The periventricular white matter is more sensitive to the systemic hemodynamic alterations than the deep white matter because of differences in its vascular structure and systemic circulation relationship. We hypothesize that periventricular white matter hyperintensity (PVWMH) volume shows greater association than deep white matter hyperintensity (DWMH) volume with vascular properties (VPs) reflecting arterial stiffness and cardiovascular remodeling, indicators of the systemic circulation. Methods and Results A total of 426 participants (age, 59.0±6.1 years; 57.5% women; and 39.7% Black race) in the Genetic Study of Atherosclerosis Risk who were aged ≥50 years and had brain magnetic resonance imaging were studied. VPs included pulse pressure, hypertensive response to exercise, diastolic brachial artery diameter, diastolic common carotid artery diameter, common carotid artery distensibility coefficient, and left ventricular function. The relative associations of VPs with PVWMH and DWMH as multiple measures within the same individual were determined using multilevel linear models. We also determined if age modified the differences in VPs associations with PVWMH and DWMH. Our findings indicated that, within the same subject, PVWMH volume had greater association than DWMH volume with pulse pressure (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.