Evidence map›Paper›PMID 35621122›Full record

ArticleClinical science (London, England : 1979)2022

Visualization of regenerating and repairing hearts.

Nevan Powers, Guo N Huang

Abstract read
In one paragraph

Article in Clinical science (London, England : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nevan PowersDepartment of Physiology, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, U.S.A.
Guo N HuangDepartment of Physiology, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, U.S.A.ORCID 0000-0002-4335-9123

Funding

Molecular control of cardiac regenerative potentialR01HL138456 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Guo Huang · 2018 to 2026
$5.1M
PB Diversity Supplement Joseph MorenoR01HL160819 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Guo Huang · 2022 to 2026
$3.0M
NHLBI NIH HHS R01 HL138456NHLBI NIH HHS R01 HL160819
6 · The paper itself

Abstract

With heart failure continuing to become more prevalent, investigating the mechanisms of heart injury and repair holds much incentive. In contrast with adult mammals, other organisms such as teleost fish, urodele amphibians, and even neonatal mammals are capable of robust cardiac regeneration to replenish lost or damaged myocardial tissue. Long-term high-resolution intravital imaging of the behaviors and interactions of different cardiac cell types in their native environment could yield unprecedented insights into heart regeneration and repair. However, this task remains challenging for the heart due to its rhythmic contraction and anatomical location. Here, we summarize recent advances in live imaging of heart regeneration and repair, discuss the advantages and limitations of current systems, and suggest future directions for novel imaging technology development.

Indexed as

HeartRegenerationAnimalsMammalsMyocardiumimaging techniquesmodel organismsmyocardial infarctionregenerationstem cell therapywound healing

Identifiers

PMID35621122
PMCPMC9886236

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.